Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24901948
DOI
10.1021/np401025f
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents pharmacology MeSH
- Benzofurans chemistry isolation & purification pharmacology MeSH
- Benzopyrans chemistry isolation & purification pharmacology MeSH
- Flavonoids chemistry isolation & purification pharmacology MeSH
- Plant Roots chemistry MeSH
- Plant Bark chemistry MeSH
- Humans MeSH
- Lipopolysaccharides pharmacology MeSH
- Macrophages drug effects MeSH
- Molecular Structure MeSH
- Morus chemistry MeSH
- Mice MeSH
- NF-kappa B drug effects MeSH
- Prenylation MeSH
- Tumor Necrosis Factor-alpha pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Benzofurans MeSH
- Benzopyrans MeSH
- cudraflavone B MeSH Browser
- Flavonoids MeSH
- Lipopolysaccharides MeSH
- morusinol MeSH Browser
- NF-kappa B MeSH
- Tumor Necrosis Factor-alpha MeSH
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
References provided by Crossref.org
Prenylated Flavonoids in Topical Infections and Wound Healing
Metabolism of Selected 2-Arylbenzofurans in a Colon In Vitro Model System
Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays
Prenylated flavonoid morusin protects against TNBS-induced colitis in rats
