Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
25517899
DOI
10.2217/fmb.14.77
Knihovny.cz E-resources
- Keywords
- Bordetella, adhesion, filamentous hemagglutinin, immunomudulation, integrins, pertussis, vaccine, virulence factors,
- MeSH
- CD47 Antigen metabolism MeSH
- Adhesins, Bacterial chemistry genetics immunology metabolism MeSH
- Bordetella pertussis immunology pathogenicity MeSH
- Virulence Factors, Bordetella chemistry genetics immunology metabolism MeSH
- Immunologic Factors * MeSH
- Humans MeSH
- Whooping Cough immunology microbiology prevention & control MeSH
- Diphtheria-Tetanus-acellular Pertussis Vaccines MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- CD47 Antigen MeSH
- Adhesins, Bacterial MeSH
- CD47 protein, human MeSH Browser
- Virulence Factors, Bordetella MeSH
- filamentous hemagglutinin adhesin, Bordetella pertussis MeSH Browser
- Immunologic Factors * MeSH
- Diphtheria-Tetanus-acellular Pertussis Vaccines MeSH
The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and β-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling capacity. Here we review the state of knowledge on this important virulence factor and acellular pertussis vaccine component. Specific emphasis is placed on outstanding questions that are yet to be answered.
References provided by Crossref.org
Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β2 Integrin CD11b/CD18
