BACKGROUND: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. AIMS: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). METHOD: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). RESULTS: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. DISCUSSION: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Department of Psychiatry University Hospital Brno Faculty of Medicine Masaryk University Brno Czech Republic;

National Institute of Mental Health Klecany Czech Republic;

National Institute of Mental Health Klecany Czech Republic; 3rd Faculty of Medicine Charles University Prague Czech Republic;

National Institute of Mental Health Klecany Czech Republic; Department of Psychiatry Dalhousie University Halifax Canada

National Institute of Mental Health Klecany Czech Republic; MR Unit ZRIR IKEM Institute for Clinical and Experimental Medicine Prague Czech Republic;

National Institute of Mental Health Klecany Czech Republic; Psychiatric Hospital Bohnice Prague Czech Republic;

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