Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26912894
DOI
10.1126/science.aad8588
PII: 351/6275/854
Knihovny.cz E-resources
- MeSH
- Diet MeSH
- Femur growth & development MeSH
- Weight Gain physiology MeSH
- Lactobacillus plantarum physiology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Malnutrition microbiology physiopathology MeSH
- Gastrointestinal Microbiome physiology MeSH
- Body Weight physiology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.
References provided by Crossref.org
Growth of the maternal intestine during reproduction
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Diet Matters: Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice
