Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26923874
DOI
10.1016/j.ccell.2016.02.001
PII: S1535-6108(16)30035-6
Knihovny.cz E-zdroje
- MeSH
- chromozomální proteiny, nehistonové genetika MeSH
- DNA vazebné proteiny genetika MeSH
- epigeneze genetická genetika MeSH
- gen SMARCB1 MeSH
- lidé MeSH
- mutace genetika MeSH
- nádory mozku genetika MeSH
- rhabdoidní nádor genetika MeSH
- teratom genetika MeSH
- transkripční faktory genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chromozomální proteiny, nehistonové MeSH
- DNA vazebné proteiny MeSH
- gen SMARCB1 MeSH
- SMARCB1 protein, human MeSH Prohlížeč
- transkripční faktory MeSH
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigenetically analyzed 192 ATRTs. Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified. Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups. Whole-genome bisulfite sequencing and H3K27Ac chromatin-immunoprecipitation sequencing of primary tumors, however, revealed clear differences, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets.
Center of Neuropathology Ludwig Maximilians Universität 81377 Munich Germany
Department of Neuropathology Academic Medical Center 20246 Amsterdam the Netherlands
Department of Neuropathology Burdenko Neurosurgical Institute 125047 Moscow Russia
Department of Neuropathology University of Bonn 53127 Bonn Germany
Department of Oncogenomics Academic Medical Center 1105 AZ Amsterdam the Netherlands
Division of Molecular Genetics German Cancer Research Center 69120 Heidelberg Germany
Division of Theoretical Bioinformatics German Cancer Research Center 69120 Heidelberg Germany
European Molecular Biology Laboratory Genome Biology Unit 69117 Heidelberg Germany
Genomics and Proteomics Core Facility German Cancer Research Center 69120 Heidelberg Germany
Institute for Human Genetics 24105 Kiel Germany
Institute of Neuropathology University Hospital Münster 48149 Münster Germany
Citace poskytuje Crossref.org
The molecular landscape of ETMR at diagnosis and relapse
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
