Striato-cortical connections in Parkinson's and Alzheimer's diseases: Relation to cognition
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
28256044
DOI
10.1002/mds.26956
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, Parkinson's disease, cognition, resting state functional connectivity, striatum,
- MeSH
- Alzheimer Disease complications diagnostic imaging physiopathology MeSH
- Corpus Striatum diagnostic imaging physiopathology MeSH
- Executive Function physiology MeSH
- Cognitive Dysfunction diagnostic imaging etiology physiopathology MeSH
- Connectome methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Cerebral Cortex diagnostic imaging physiopathology MeSH
- Parkinson Disease complications diagnostic imaging physiopathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Functional connectivity is abnormal in PD and in early Alzheimer's disease. OBJECTIVES: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. METHODS: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. RESULTS: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. CONCLUSIONS: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society.
References provided by Crossref.org
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