Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články
PubMed
28263525
PII: NEL370916A01
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- kovové nanočástice škodlivé účinky MeSH
- látky znečišťující vzduch škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci z povolání krev MeSH
- oxidační stres * MeSH
- pilotní projekty MeSH
- pracovní expozice škodlivé účinky MeSH
- titan škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- látky znečišťující vzduch MeSH
- titan MeSH
OBJECTIVES: Experimental studies using nanoscale TiO2 have documented lung injury, inflammation, oxidative stress, and genotoxicity. Human health data are extremely scarce. METHODS: In exhaled breath condensate (EBC) and urine of 22 office employees occupationally exposed to TiO2 during their visit in the production workshops for average 14±9 min/day a panel of biomarkers of nucleic acids and proteins oxidation was studied, specifically 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU), o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr), and 3-nitrotyrosine (3-NOTyr). Examination was performed also in 14 comparable controls. RESULTS: The median respirable TiO2 mass concentration in the workshops was 0.40 mg/m3, median number concentration was 2.32×104 particles/cm3 with 80% of the particles being <100 nm in diameter. All 6 markers of oxidation were elevated in EBC in factory office employees relative to controls (p<0.01). Significant association was found between their job in TiO2 production plant and 5 markers of oxidation (except 3-NOTyr) in the EBC in multivariate analysis. No elevation of markers was detected in the urine. CONCLUSION: This pilot study suggests that even short nanoTiO2 exposure may lead to pulmonary oxidative stress; however this effect may be short-term and reversible. The clinical significance of these findings is unclear and more studies are needed.
Institute of Chemical Process Fundamentals of the CAS CR v v i Prague Czech Republic
Institute of Chemical Technology Prague Czech Republic
J Heyrovský Institute of Physical Chemistry of the CAS CR v v i Prague Czech Republic
Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers
Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites
