Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease
Jazyk angličtina Země Rakousko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
28271290
DOI
10.1007/s00702-017-1703-1
PII: 10.1007/s00702-017-1703-1
Knihovny.cz E-zdroje
- Klíčová slova
- Arterial spin labelling, Cognitive performance, Parkinson’s disease, Perfusion,
- MeSH
- cerebrovaskulární poruchy diagnostické zobrazování patofyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie * MeSH
- mozková kůra diagnostické zobrazování patofyziologie MeSH
- mozkový krevní oběh fyziologie MeSH
- Parkinsonova nemoc diagnostické zobrazování patofyziologie psychologie MeSH
- počítačové zpracování obrazu MeSH
- pohybová aktivita MeSH
- průřezové studie MeSH
- senioři MeSH
- spinové značení MeSH
- stupeň závažnosti nemoci MeSH
- zobrazování trojrozměrné MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- spinové značení MeSH
While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years ± 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years ± 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.
Department of Paediatrics University of Minnesota Minneapolis MN USA
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Nat Neurosci. 2000 Jan;3(1):91-6 PubMed
J Magn Reson Imaging. 2011 Apr;33(4):803-7 PubMed
PeerJ. 2015 Mar 17;3:e834 PubMed
Neuroimage. 2004 May;22(1):443-6 PubMed
J Neural Transm (Vienna). 2012 Apr;119(4):443-54 PubMed
J Alzheimers Dis. 2010;20(3):871-80 PubMed
AJNR Am J Neuroradiol. 2015 Oct;36(10):1816-21 PubMed
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18035-40 PubMed
Alzheimers Dement. 2012 Jan;8(1):51-9 PubMed
J Cereb Blood Flow Metab. 2014 Jun;34(6):964-70 PubMed
Sci Rep. 2015 Jul 15;5:12125 PubMed
J Alzheimers Dis. 2014;42 Suppl 3:S217-28 PubMed
Neurology. 2011 Nov 29;77(22):1977-85 PubMed
J Neuroimaging. 2016 Mar-Apr;26(2):207-12 PubMed
Medicine (Baltimore). 2016 Feb;95(5):e2206 PubMed
Neurology. 2012 Dec 4;79(23):2226-32 PubMed
Brain. 2006 Mar;129(Pt 3):564-83 PubMed
J Cereb Blood Flow Metab. 2010 Mar;30(3):505-9 PubMed
Neurology. 2011 Oct 4;77(14 ):1357-62 PubMed
PeerJ. 2014 Dec 11;2:e687 PubMed
Neuroimage. 2003 Dec;20(4):1934-43 PubMed
Neuroimage. 2005 Oct 1;27(4):824-34 PubMed
J Psychiatr Res. 1975 Nov;12(3):189-98 PubMed
Anat Embryol (Berl). 2005 Dec;210(5-6):463-72 PubMed
Trends Neurosci. 2009 Oct;32(10 ):548-57 PubMed
Brain. 2009 Nov;132(Pt 11):2958-69 PubMed
Hum Brain Mapp. 2014 Sep;35(9):4916-31 PubMed
Mov Disord. 2009 Apr 30;24(6):854-62 PubMed
Neurology. 2009 Nov 24;73(21):1738-45 PubMed
Int J Geriatr Psychiatry. 2006 Nov;21(11):1078-85 PubMed
Brain. 2011 Mar;134(Pt 3):845-55 PubMed
Mov Disord. 2015 Dec;30(14 ):1893-900 PubMed
Neuroimage Clin. 2014 Aug 01;6:1-8 PubMed
Mov Disord. 2009 Jul 30;24(10 ):1504-11 PubMed
Mov Disord. 2010 Nov 15;25(15):2649-53 PubMed
Curr Protoc Neurosci. 2009 Oct;Chapter 10:Unit10.1 PubMed
Mov Disord. 2015 Oct;30(12):1591-601 PubMed
Brain Lang. 2013 Nov;127(2):230-40 PubMed
Mov Disord. 2009 Jun 15;24(8):1193-9 PubMed
Neurology. 2008 Apr 15;70(16 Pt 2):1470-7 PubMed
Neuroimage. 2012 Feb 1;59(3):2743-50 PubMed
Magn Reson Med. 2000 Sep;44(3):450-6 PubMed
Brain. 2000 Feb;123 ( Pt 2):340-52 PubMed
J Cogn Neurosci. 2000 Jan;12(1):1-47 PubMed
Exp Gerontol. 2014 Dec;60:31-6 PubMed
Parkinsons Dis. 2015;2015:579417 PubMed
Eur J Nucl Med Mol Imaging. 2012 Nov;39(11):1767-77 PubMed
