Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
28401285
DOI
10.1007/s00213-017-4601-1
PII: 10.1007/s00213-017-4601-1
Knihovny.cz E-resources
- Keywords
- Cannabis, Cortisol, Dopamine, Hypoactive sexual desire, Hypothalamus, Nucleus accumbens, Prolactin, fMRI,
- MeSH
- Cannabis metabolism toxicity MeSH
- Erotica MeSH
- Drug Combinations MeSH
- Hydrocortisone blood MeSH
- Hypnotics and Sedatives MeSH
- Cannabidiol blood chemistry MeSH
- Libido ethics physiology MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain physiology MeSH
- Nucleus Accumbens MeSH
- Pilot Projects MeSH
- Prolactin blood MeSH
- Dronabinol blood chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Drug Combinations MeSH
- Hydrocortisone MeSH
- Hypnotics and Sedatives MeSH
- Cannabidiol MeSH
- nabiximols MeSH Browser
- Prolactin MeSH
- Dronabinol MeSH
RATIONALE: Self-report studies indicate that cannabis could increase sexual desire in some users. We hypothesized that intoxication increases activation of brain areas responsive to visual erotica, which could be useful in the treatment of hypoactive sexual desire disorder, a condition marked by a lack of sexual desire. OBJECTIVES: The aim of this study is to assess the aphrodisiacal properties of cannabis. METHODS: We conducted an open-randomized study with 21 heterosexual casual cannabis users. A 3T MRI was used to measure brain activation in response to erotic pictures. Blood samples were collected to determine the serum levels of cannabinoids, cortisol and prolactin. Participants were grouped according to whether they had ever experienced any aphrodisiacal effects during intoxication (Group A) or not (Group non-A). RESULTS: Intoxication was found to significantly increase activation in the right nucleus accumbens in the Group A while significantly decreasing activation in the Group non-A. There was also a significant interaction between the group and intoxication, with elevated prolactin in the Group non-A during intoxication. No intoxication-related differences in subjective picture evaluations were found. CONCLUSION: Cannabis intoxication increases activation of the right nucleus accumbens to erotic stimuli. This effect is limited to users whose prolactin is not elevated in response to intoxication. This effect may be useful in the treatment of low sexual desire.
3rd Medical Faculty Charles University Prague Czech Republic
Institute of clinical and experimental medicine Prague Czech Republic
National Institute of Mental Health Topolova 748 250 67 Klecany Czech Republic
Police of the Czech Republic Institute of criminalistics Prague Prague Czech Republic
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