Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
28673719
DOI
10.1016/j.neuroscience.2017.06.034
PII: S0306-4522(17)30439-6
Knihovny.cz E-resources
- Keywords
- ABAD modulators, Alzheimer’s disease, cholinesterase inhibitors, mPTP modulators, monoamine oxidase (MAO) inhibitors,
- MeSH
- Acetylcholine metabolism MeSH
- Alzheimer Disease drug therapy metabolism MeSH
- Biogenic Monoamines metabolism MeSH
- Energy Metabolism drug effects MeSH
- Central Nervous System Agents chemistry pharmacology therapeutic use MeSH
- Humans MeSH
- Synaptic Transmission drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Acetylcholine MeSH
- Biogenic Monoamines MeSH
- Central Nervous System Agents MeSH
Current options for Alzheimer's disease (AD) treatment are based on administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or memantine, acting as an N-methyl-D-aspartate (NMDA). Therapeutic approaches vary and include novel cholinesterase inhibitors, modulators of NMDA receptors, monoamine oxidase (MAO) inhibitors, immunotherapeutics, modulators of mitochondrial permeability transition pores (mPTP), amyloid-beta binding alcohol dehydrogenase (ABAD) modulators, antioxidant agents, etc. The novel trends of AD therapy are focused on multiple targeted ligands, where mostly ChE inhibition is combined with additional biological properties, positively affecting neuronal energy metabolism as well as mitochondrial functions, and possessing antioxidant properties. The present review summarizes newly developed drugs targeting cholinesterase and MAO, as well as drugs affecting mitochondrial functions.
References provided by Crossref.org
Profiling donepezil template into multipotent hybrids with antioxidant properties
