Fully grown oocytes arrest meiosis at prophase I and deposit maternal RNAs. A subset of maternal transcripts is stored in a dormant state in the oocyte, and the timely driven translation of specific mRNAs guides meiotic progression, the oocyte-embryo transition, and early embryo development. In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization and at the level of protein synthesis.This chapter focuses on the recent findings on RNA distribution related to the temporal and spatial translational control of the meiotic cycle progression in mammalian oocytes. We discuss the most relevant mechanisms involved in the organization of the oocyte's maternal transcriptome storage and localization, and the regulation of translation, in correlation with the regulation of oocyte meiotic progression.

Institute of Animal Physiology and Genetics CAS Rumburska 89 277 21 Libechov Czech Republic

References provided by Crossref.org

Spatiotemporal dynamics and selectivity of mRNA translation during mouse pre-implantation development

Spatiotemporal dynamics and selectivity of mRNA translation during mouse pre-implantation development

The translational oscillation in oocyte and early embryo development

ncRNA BC1 influences translation in the oocyte

Impact of Global Transcriptional Silencing on Cell Cycle Regulation and Chromosome Segregation in Early Mammalian Embryos

Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

Identifying the Translatome of Mouse NEBD-Stage Oocytes via SSP-Profiling; A Novel Polysome Fractionation Method

Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes

Localization of RNA and translation in the mammalian oocyte and embryo

Regulation of 4E-BP1 activity in the mammalian oocyte