The state-of-art in the lipidomic analysis is summarized here to provide the overview of available sample preparation strategies, mass spectrometry (MS)-based methods for the qualitative analysis of lipids, and the quantitative MS approaches for high-throughput clinical workflows. Major challenges in terms of widely accepted best practices for lipidomic analysis, nomenclature, and standards for data reporting are discussed as well.

Department of Analytical Chemistry Faculty of Chemical Technology University of Pardubice Studentská 573 53210 Pardubice Czech Republic

Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg 93053 Regensburg Germany

Lipidomics Consulting Ltd 02230 Esbo Finland

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Four-Dimensional Lipidomic Analysis Using Comprehensive Online UHPLC × UHPSFC/Tandem Mass Spectrometry

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Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS

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Plasma lipidomic profiles of kidney, breast and prostate cancer patients differ from healthy controls

Mass Spectrometry-Based Lipidomics Reveals Differential Changes in the Accumulated Lipid Classes in Chronic Kidney Disease

Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis