The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
30055896
DOI
10.1016/j.tibs.2018.06.009
PII: S0968-0004(18)30126-9
Knihovny.cz E-zdroje
- Klíčová slova
- inhibitor, intramembrane protease, mechanism, pseudoenzyme, signaling, structure,
- MeSH
- lidé MeSH
- membránové proteiny genetika metabolismus MeSH
- protein ADAM17 genetika metabolismus MeSH
- proteolýza * MeSH
- signální transdukce fyziologie MeSH
- TNF-alfa genetika metabolismus MeSH
- transport proteinů fyziologie MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- ADAM17 protein, human MeSH Prohlížeč
- membránové proteiny MeSH
- protein ADAM17 MeSH
- TNF-alfa MeSH
The rhomboid superfamily of transmembrane (TM) proteins includes intramembrane serine proteases and several classes of pseudoprotease. Rhomboid-like proteins occur widely across evolution and comprise biologically important regulators of fate of membrane proteins, influencing their proteolysis, trafficking, or degradation. In this review, we discuss how structural and mechanistic insights into the action of rhomboid proteases can inform on the mechanism of the pseudoproteases, and discuss the impact of structural understanding on the development of inhibitors and other chemical biology tools for these proteins. Development of modulators would be particularly relevant for the iRhoms, which are key regulators of ADAM17 and, hence, tumor necrosis factor (TNF) and epidermal growth factor receptor (EGFR) signaling, two medically important pathways.
Citace poskytuje Crossref.org
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4
