Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially masking the effects of PAHSAs in studies utilizing this vehicle.

Department of Adipose Tissue Biology Institute of Physiology of the Czech Academy of Sciences Videnska 1083 142 20 Prague Czech Republic

Cell Metab. 2018 Aug 7;28(2):217-227.e13. doi: 10.1016/j.cmet.2018.05.028. PubMed

References provided by Crossref.org

Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids

Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice

Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice