Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
16-27075A
Ministry of Health of the Czech Republic, Czech Health Research Council AZV - International
RVO-VFN 64165
Ministry of Health of the Czech Republic - International
First Faculty of Medicine, Charles University - International
PubMed
31074872
DOI
10.1111/acer.14077
Knihovny.cz E-zdroje
- Klíčová slova
- Basal Ganglia, Methanol Poisoning, Psychomotor Speed, Subcortical White Matter, Sustained Visual Attention,
- MeSH
- bazální ganglia diagnostické zobrazování MeSH
- bílá hmota diagnostické zobrazování MeSH
- dospělí MeSH
- exekutivní funkce účinky léků MeSH
- kognice účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- methanol otrava MeSH
- mozek diagnostické zobrazování MeSH
- následné studie MeSH
- nervová síť diagnostické zobrazování MeSH
- neuropsychologické testy MeSH
- paměť účinky léků MeSH
- pozornost účinky léků MeSH
- přežívající MeSH
- průřezové studie MeSH
- psychomotorický výkon účinky léků MeSH
- senioři MeSH
- učení účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- methanol MeSH
BACKGROUND: Acute methanol poisoning leads to optic neuropathy and necrotic lesions of basal ganglia (BG) and subcortical white matter. Survivors of methanol poisoning exhibit long-term executive and memory deficits. Associations between brain volumetry parameters and cognitive sequelae of methanol poisoning are not known. The aim of our study was to identify long-term associations between the cognitive performance of survivors of methanol poisoning and the volume of the brain structures that are selectively vulnerable to methanol. METHODS: We conducted a cross-sectional follow-up study on a sample of patients (n = 33, age 50 ± 14 years, 82% males) who survived acute methanol poisoning during methanol mass poisoning outbreak from September 2012 till January 2013 in the Czech Republic. A battery of neuropsychological tests and brain magnetic resonance imaging were included in the clinical examination protocol. Specific brain structures (putamen, globus pallidus, nucleus caudatus, and frontal white matter) were selected as regions of interest, and their volumes were estimated using the MorphoBox prototype software. RESULTS: In robust multiple regression models, sustained visual attention performance (as assessed by Trail Making Test and Prague Stroop Test) was positively associated with BG structures and frontal white matter volumes (Wald = 9.03 to 85.50, p < 0.01), sensitivity to interference (as assessed by Frontal Battery Assessment) was negatively associated with frontal white matter volume (Wald = 35.44 to 42.25, p < 0.001), and motor performance (as assessed by Finger Tapping Test) was positively associated with globus pallidus and frontal white matter volumes (Wald = 9.66 to 13.29, p < 0.01). CONCLUSIONS: Our results demonstrate that smaller volumes of elements of BG-thalamocortical circuitry, namely the BG and frontal white matter, relate to attention and motor performance in methanol poisoning from a long-term perspective. Disruption of those functional circuits may underlie specific cognitive deficits observed in methanol poisoning.
Advanced Clinical Imaging Technology Siemens Healthcare AG Lausanne Switzerland
Department of Radiology University Hospital Lausanne Lausanne Switzerland
Institute of Anatomy 1st Faculty of Medicine Charles University Prague Czech Republic
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