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Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta

. 2019 Aug ; 46 (4) : 4453-4461. [epub] 20190607

Language English Country Netherlands Media print-electronic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/pmid31175514

Grant support
CZ.1.05/1.1.00/02 Central European Institute of Technology
NPU LQ1601 Ministerstvo Školství, Mládeže a Tělovýchovy

Links

PubMed 31175514
DOI 10.1007/s11033-019-04900-w
PII: 10.1007/s11033-019-04900-w
Knihovny.cz E-resources

The West Nile virus (WNV) is a mosquito-borne flavivirus causing meningoencephalitis in humans and animals. Due to their particular susceptibility to WNV infection, horses serve as a sentinel species. In a population of Romanian semi-feral horses living in the Danube delta region, we have analyzed the distribution of candidate polymorphic genetic markers between anti WNV-IgG seropositive and seronegative horses. Thirty-six SNPs located in 28 immunity-related genes and 26 microsatellites located in the MHC and LY49 complex genomic regions were genotyped in 57 seropositive and 32 seronegative horses. The most significant association (pcorr < 0.0002) was found for genotypes composed of markers of the SLC11A1 and TLR4 genes. Markers of five other candidate genes (ADAM17, CXCR3, IL12A, MAVS, TNFA), along with 5 MHC class I and LY49-linked microsatellites were also associated with the WNV antibody status in this model horse population. The OAS1 gene, previously associated with WNV-induced clinical disease, was not associated with the presence of anti-WNV antibodies.

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