Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
32151633
DOI
10.1016/j.bbadis.2020.165759
PII: S0925-4439(20)30104-6
Knihovny.cz E-zdroje
- Klíčová slova
- Bioenergetics, Cancer, De novo pyrimidine synthesis, Dehydroorotate dehydrogenase, Oxidative phosphorylation,
- MeSH
- dihydroorotátdehydrogenasa MeSH
- inhibitory enzymů terapeutické užití MeSH
- lidé MeSH
- mitochondrie genetika metabolismus MeSH
- nádory genetika patologie MeSH
- oxidativní fosforylace * MeSH
- oxidoreduktasy působící na CH-CH vazby antagonisté a inhibitory genetika MeSH
- proliferace buněk účinky léků MeSH
- transport elektronů genetika MeSH
- ubichinon analogy a deriváty genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- coenzyme Q10 MeSH Prohlížeč
- dihydroorotátdehydrogenasa MeSH
- inhibitory enzymů MeSH
- oxidoreduktasy působící na CH-CH vazby MeSH
- ubichinon MeSH
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
Institute of Biotechnology Czech Academy of Sciences BIOCEV 252 50 Vestec Prague West Czech Republic
Citace poskytuje Crossref.org
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