Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
32151633
DOI
10.1016/j.bbadis.2020.165759
PII: S0925-4439(20)30104-6
Knihovny.cz E-resources
- Keywords
- Bioenergetics, Cancer, De novo pyrimidine synthesis, Dehydroorotate dehydrogenase, Oxidative phosphorylation,
- MeSH
- Dihydroorotate Dehydrogenase MeSH
- Enzyme Inhibitors therapeutic use MeSH
- Humans MeSH
- Mitochondria genetics metabolism MeSH
- Neoplasms genetics pathology MeSH
- Oxidative Phosphorylation * MeSH
- Oxidoreductases Acting on CH-CH Group Donors antagonists & inhibitors genetics MeSH
- Cell Proliferation drug effects MeSH
- Electron Transport genetics MeSH
- Ubiquinone analogs & derivatives genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- coenzyme Q10 MeSH Browser
- Dihydroorotate Dehydrogenase MeSH
- Enzyme Inhibitors MeSH
- Oxidoreductases Acting on CH-CH Group Donors MeSH
- Ubiquinone MeSH
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
Institute of Biotechnology Czech Academy of Sciences BIOCEV 252 50 Vestec Prague West Czech Republic
References provided by Crossref.org
Rhodoquinone carries electrons in the mammalian electron transport chain
Mitochondrial Physiology of Cellular Redox Regulations
Mitochondria on the move: Horizontal mitochondrial transfer in disease and health
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities
Miro proteins and their role in mitochondrial transfer in cancer and beyond
