Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula
Language English Country Switzerland Media print-electronic
Document type Journal Article
PubMed
33530085
DOI
10.1159/000513071
PII: 000513071
Knihovny.cz E-resources
- Keywords
- Angiotensin II, Aortocaval fistula, Congestive heart failure, Hypertension, Renal blood flow, Renal denervation, Renal vascular reactivity,
- MeSH
- Angiotensin II metabolism MeSH
- Arteriovenous Fistula complications MeSH
- Hypertension complications genetics metabolism MeSH
- Rats MeSH
- Kidney innervation surgery MeSH
- Rats, Sprague-Dawley MeSH
- Rats, Transgenic MeSH
- Renin genetics MeSH
- Heart Failure complications genetics metabolism therapy MeSH
- Sympathectomy * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Angiotensin II MeSH
- Renin MeSH
OBJECTIVE: We examined if renal denervation (RDN) attenuates the progression of aortocaval fistula (ACF)-induced heart failure or improves renal hemodynamics in Ren-2 transgenic rats (TGR), a model of angiotensin II (ANG II)-dependent hypertension. METHODS: Bilateral RDN was performed 1 week after creation of ACF. The animals studied were ACF TGR and sham-operated controls, and both groups were subjected to RDN or sham denervation. In separate groups, renal artery blood flow (RBF) responses were determined to intrarenal ANG II (2 and 8 ng), norepinephrine (NE) (20 and 40 ng) and acetylcholine (Ach) (10 and 40 ng) 3 weeks after ACF creation. RESULTS: In nondenervated ACF TGR, the final survival rate was 10 versus 50% in RDN rats. RBF was significantly lower in ACF TGR than in sham-operated TGR (6.2 ± 0.3 vs. 9.7 ± 0.5 mL min-1 g-1, p < 0.05), the levels unaffected by RDN. Both doses of ANG II decreased RBF more in ACF TGR than in sham-operated TGR (-19 ± 3 vs. -9 ± 2% and -47 ± 3 vs. -22 ± 2%, p < 0.05 in both cases). RDN did not alter RBF responses to the lower dose, but increased it to the higher dose of ANG II in sham-operated as well as in ACF TGR. NE comparably decreased RBF in ACF TGR and sham-operated TGR, and RDN increased RBF responsiveness. Intrarenal Ach increased RBF significantly more in ACF TGR than in sham-operated TGR (29 ± 3 vs. 17 ± 3%, p < 0.05), the changes unaffected by RDN. ACF creation induced marked bilateral cardiac hypertrophy and lung congestion, both attenuated by RDN. In sham-operated but not in ACF TGR, RDN significantly decreased mean arterial pressure. CONCLUSION: The results show that RDN significantly improved survival rate in ACF TGR; however, this beneficial effect was not associated with improvement of reduced RBF or with attenuation of exaggerated renal vascular responsiveness to ANG II.
Center for Experimental Medicine Institute for Clinical and Experimental Medicine Prague Czechia
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czechia
Department of Pathology 3rd Faculty of Medicine Charles University Prague Czechia
Department of Physiology Faculty of Science Charles University Prague Prague Czechia
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