Improvement of Memory Functions in Chronic Spinal Cord Injury After Long-Term Intrathecal Baclofen Delivery for Spasticity Relief
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
00023884
Ministerstvo Zdravotnictví Ceské Republiky
Univerzita Karlova v Praze
PubMed
33533153
DOI
10.1111/ner.13340
PII: S1094-7159(21)06449-7
Knihovny.cz E-zdroje
- Klíčová slova
- Chronic spinal cord injury, intrathecal baclofen, memory, neuropsychological assessment,
- MeSH
- baklofen terapeutické užití MeSH
- centrálně působící myorelaxancia * terapeutické užití MeSH
- implantabilní infuzní pumpy MeSH
- lidé MeSH
- poranění míchy * komplikace farmakoterapie MeSH
- spinální injekce MeSH
- svalová spasticita farmakoterapie etiologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- baklofen MeSH
- centrálně působící myorelaxancia * MeSH
BACKGROUND: Intrathecal baclofen (ITB) pump delivery systems are safe and effective in the treatment of generalized spasticity in chronic spinal cord injury (SCI). Despite its widespread use, few and discrepant data are available in animal studies on the effects of ITB on cognitive functions, such as memory. The effects of chronic administration of baclofen on humans have not been investigated to date. The aim of this study is to find out, whether a long-term administration of ITB has any effects on cognitive functions in SCI subjects. MATERIALS AND METHODS: In 11 out of 22 subjects with chronic SCI, we performed comprehensive neuropsychological assessment carried out using specialized tests focused on memory and other higher cognitive domains and emotional state. RESULTS: All patients receiving ITB treatment for spasticity relief improved significantly in RAVLT Trials 1-5 (p = 0.049), Logical memory-immediate recall (p = 0.019) and Logical memory-delayed recall (p = 0.008). Visual memory, long-term semantic memory, attention, executive, perceptual and spatial functions, and mood status remained stable. CONCLUSION: No significant decline in memory functions were detected following one year of ITB delivery, creating an opportunity for careful prescription of this treatment in chronic SCI. Moreover, we have detected a significant increase in short-term auditory-verbal memory and logical memory performance.
Department of Clinical Psychology Na Homolce Hospital Prague Czech Republic
Department of Psychology Faculty of Arts Charles University Prague Czech Republic
Department of Radiology Na Homolce Hospital Prague Czech Republic
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