Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cell Line MeSH
- Kidney drug effects metabolism MeSH
- Humans MeSH
- Molecular Structure MeSH
- Oximes administration & dosage adverse effects chemistry MeSH
- Cholinesterase Reactivators administration & dosage adverse effects chemistry MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oximes MeSH
- Cholinesterase Reactivators MeSH
Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.
References provided by Crossref.org
Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
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