Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire

. 2024 Sep 01 ; 42 (9) : 1544-1554. [epub] 20240513

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid38747416
Odkazy

PubMed 38747416
DOI 10.1097/hjh.0000000000003756
PII: 00004872-202409000-00012
Knihovny.cz E-zdroje

OBJECTIVE: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. METHODS: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management quality. RESULTS: Overall, 88 ESH-ECs from 27 countries participated (fully completed surveys: 66/88 [75.0%]). ESH-ECs reported that 28% (median, interquartile range: 15-50%) had preexisting CKD, with 10% of them (5-30%) previously referred to a nephrologist, while 30% (15-40%) had resistant hypertension. The reported rate of previous recent (<6 months) estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) testing were 80% (50-95%) and 30% (15-50%), respectively. The reported use of renin-angiotensin system blockers was 80% (70-90%). When a nephrologist was part of the ESH-EC teams the reported rates SGLT2 inhibitors (27.5% [20-40%] vs. 15% [10-25], P = 0.003), GLP1-RA (10% [10-20%] vs. 5% [5-10%], P = 0.003) and mineralocorticoid receptor antagonists (20% [10-30%] vs. 15% [10-20%], P = 0.05) use were greater as compared to ESH-ECs without nephrologist participation. The rate of reported resistant hypertension, recent eGFR and UACR results and management of CKD patients prior to referral varied widely across countries. CONCLUSIONS: Our estimation indicates deficits regarding CKD screening, use of nephroprotective drugs and referral to nephrologists before referral to ESH-ECs but results varied widely across countries. This information can be used to build specific programs to improve care in hypertensives with CKD.

1st Department of Cardiology National and Kapodistrian University of Athens Hippocratio Hospital Greece

1st Department of Internal Medicine Cardiology Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Czech Republic

2nd Deparment od Internal Medicine of St Anne's University Hospital Brno and Fakulty of Medicine Masaryk University Brno Czechia

2nd Department of Cardiology Medical School University of Athens ATTIKON Hospital Athens

2nd Prop Department of Internal Medicine Aristotle University Thessaloniki Greece

3rd Department of Internal Medicine Papageorgiou Hospital Aristotle University of Thessaloniki Greece

AP HP Unité d'hypertension artérielle service de médecine interne Hôpital Avicenne Bobigny France

Cardiovascular Risk and Hypertension Hospital Madrid Spain

Cardiovascular Risk Clinic Western General Hospital Edinburgh UK

Center of Preventive Cardiology Hospital N2 CJSC Yerevan Armenia

Centre for Hypertension 3rd Internal Department General Faculty Hospital Charles University Prague Czech Republic

Centre of Cardiology North Estonia Medical Centre Tallinn University of Technology Tallinn Estonia

Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin Institute of Clinical Pharmacology and Toxicology Berlin Germany

Charité Universitätsmedizin Berlin Medinische Klinik für Nephrologie und internistische Intensivtherapie Berlin Germany

Clinica di Medicina Interna 2 Università degli Studi e IRCCS Ospedale Policlinico San Martino di Genova

Clinica Medica University Milano Bicocca Milan Italy

Department of Advanced Medical Sciences Federico 2 University of Naples Naples Italy

Department of Cardiology Abdali Hospital Amman Jordan

Department of Cardiology Istituto Auxologico Italiano IRCCS Milan Italy; Department of Medicine and Surgery University of Milano Bicocca Milan Italy

Department of Cardiology LAIKO General Hospital Athens Greece

Department of Cardiology Medical University of Graz Graz Austria

Department of Cardiovascular Diseases Internal Medicine University Hospital Ghent Ghent Belgium

Department of Clinical and Experimental Sciences University of Brescia and ASST Spedali Civili Italy

Department of Clinical Sciences Lund University Skane University Hospital Malmö Sweden

Department of Heart Disease Haukeland University Hospital Bergen Norway

Department of Internal Medicine 4 ; Medical University Innsbruck Austria

Department of Internal Medicine and Cardiology University Hospital Ostrava and Faculty of Medicine University of Ostrava Czech Republic

Department of Internal Medicine Montpellier University Hospital Montpellier France and PhyMedExp INSERM U1046 CNRS UMR 9214 University of Montpellier Montpellier France

Department of Internal Medicine Nephrology Heinrich Heine University Duesseldorf Duesseldorf Germany

Department of Internal Medicine Section of Nephrology Amsterdam University Medical Center Amsterdam Cardiovascular Sciences University of Amsterdam Amsterdam The Netherlands

Department of Medical Sciences University of Turin Turin Italy

Department of Medicine and Surgery University of Perugia Unit of Internal Medicine Santa Maria Terni Hospital Terni Italy

Department of Medicine Radboud University Medical Center Nijmegen The Netherlands

Department of Nephrology and Hypertension University Hospital Erlangen Friedrich Alexander University Erlangen Nürnberg Erlangen Germany

Department of Nephrology Cantonal Hospital Graubuenden Chur Switzerland

Department of Nephrology Helsinki University Hospital and University of Helsinki Biomedicum 2 Helsinki Helsinki Finland

Division of Cardiology Department of Cardiovascular Diseases Cliniques Universitaires Saint Luc and Pole of Cardiovascular Research Institut de Recherche Expérimentale et Clinique Université Catholique de Louvain Brussels Belgium

Division of Medicine Turku University Hospital Turku University Turku Finland

Division of Nephrology University of Liège Hospital Cardiovascular Sciences University of Liège Liège Belgium

Emergency Clinical Hospital of Bucharest Bucharest Romania

ESH Excellent Center Hypertension LAIKO University Hospital Athens Greece

Faculty of Medicine Oporto Portugal

Grande Ospedale Metropolitano UOC di Nefrologia abilitata al trapianto renale CNR Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell'Ipertensione Arteriosa Reggio Calabria Italy

Hôpital Ed Herriot Department of Nephrology and Hypertension Lyon

Hospital Centre of Vila Nova de Gaia Espinho Internal Medicine Department Hypertension and Cardiometabolic Risk Unit ESH Excellence Centre Vila Nova de Gaia Portugal

Hospital Universitario de Badajoz Badajoz Spain

Hypertension and Vascular Risk Unit Department of Nephrology Hospital del Mar IMIM Universitat Pompeu Fabra Barcelona Catalonia Spain

Hypertension Center Department of Nephrology and Hypertension Hannover Medical School Hannover Germany

Hypertension Center STRIDE 7 National and Kapodistrian University of Athens School of Medicine 3rd Department of Medicine Sotiria Hospital Athens Greece

Hypertension Clinic Hadassah Hebrew University Medical Center Mount Scopus Jerusalem and Faculty of Medicine Hadassah Hebrew University School of Medicine Jerusalem Israel

Hypertension Outpatient Clinic Cardiology Department Heraklion University General Hospital Heraklion Crete Greece

Hypertension Unit Department of Cardiology HELORA University Hospitals Mons Belgium

Hypertension Unit Department of Internal Medicine Hospital Clinic University of Barcelona Spain

Hypertension Unit Department of Internal Medicine University Hospital of Heraklion Heraklion

Hypertension Unit KAT General Hospital of Attica Attica Greece

Hypertension Unit of the 1st Department of Medicine Aristotle University of Thessaloniki AHEPA Hospital Thessaloniki

Hypertoniezentrum Bonn Schwerpunktpraxis Kardiologie Angiologie Prävention Rehabilitation Bonn Germany

Izmir Medicana International Hospital Division of Cardiology Konak Izmir Turkey

Karolinska Institutet Department of Clinical Sciences Division of Cardiovascular Medicine Stockholm Sweden; and Danderyd University Hospital Corp Department of Cardiology Stockholm Sweden

Klinikum Wels Grieskirchen

Medical Outpatient Department and Hypertension Clinic University Hospital Basel Basel Switzerland

Medical University of Warsaw Warsaw Poland

Metropolitan Hospital Piraeus

Peart Rose Clinic Hammersmith Hospital Imperial College Healthcare Trust London UK

Plava Medical Group Sarajevo Bosnia and Herzegovina

PROMISE Department Nephrology and Dialysis Unit with Hypertension ESH Excellence Centre University Hospital P Giaccone; University of Palermo Palermo Italy

School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece

Service d'HTA et Therapeutique CHU Rangueil Toulouse University Toulouse

Service de cardiologie Hôpital de la Timone Marseille France

Service de Médecine Interne Hôpital Franco Britannique Levallois Perret France

Service de Néphrologie CIC CRB 1404 INSERM EnVi U1096 CHU Rouen Rouen France

Service de néphrologie et d'hypertension Lausanne University Hospital and University of Lausanne Lausanne Switzerland

Service de Néphrologie Hypertension Dialyses Transplantation rénale Hôpital Bretonneau CHU Tours Tours France

Service de Néphrologie transplantation dialyse aphérèses CHU Bordeaux France

South Buda Center Hospital St Imre University Teaching Hospital Budapest Hungary

St George University Medical Center Achrafieh Beirut Lebanon

St Josefs Hospital Cloppenburg Germany

UF Hypertension et Athérothrombose Centre Européen d'Excellence en Hypertension Artérielle Service de Cardiologie Pôle Thorax et Vaisseaux CHU Michallon Grenoble France

Università Politecnica delle Marche and IRCCS INRCA Ancona Italy

Universitair Ziekenhuis Brussel VUB Belgium

Université Paris Cité Paris France; APHP Service d'Hypertension Artérielle Hôpital Européen Georges Pompidou Paris France

University Hospital of North Norway Tromsø Norway

University Hospital Zurich University Heart Center Cardiology and University of Zurich Zurich Switzerland

UOC Medicina Interna Centro Ipertensione di Eccellenza Europea ESH Azienda ULSS 5 Polesana Ospedale di Adria Italy

Vascular Risk Unit Internal Medicine Virgen de las Nieves University Hospital Granada Spain

Zobrazit více v PubMed

Mancia G, Kreutz R, Brunstrom M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens 2023; 41:1874–2071.

Kidney Disease: Improving Global Outcomes Blood Pressure Work Group. KDIGO 2021 clinical practice guideline for the management of blood pressure in chronic kidney disease. Kidney Int 2021; 99 (3S):S1–S87.

Malhotra R, Nguyen HA, Benavente O, Mete M, Howard BV, Mant J, et al. Association between more intensive vs less intensive blood pressure lowering and risk of mortality in chronic kidney disease stages 3 to 5: a systematic review and meta-analysis. JAMA Intern Med 2017; 177:1498–1505.

Aggarwal R, Petrie B, Bala W, Chiu N. Mortality outcomes with intensive blood pressure targets in chronic kidney disease patients. Hypertension 2019; 73:1275–1282.

Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, et al. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 2002; 288:2421–2431.

Strippoli GF, Craig M, Deeks JJ, Schena FP, Craig JC. Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review. BMJ 2004; 329:828.

Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345:861–869.

Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345:851–860.

Agarwal R. Hypertension: KDIGO BP guidelines—more individualized, less prescriptive. Nat Rev Nephrol 2013; 9:131–133.

Assogba GF, Couchoud C, Roudier C, Pornet C, Fosse S, Romon I, et al. Prevalence, screening and treatment of chronic kidney disease in people with type 2 diabetes in France: the ENTRED surveys (2001 and 2007). Diabetes Metab 2012; 38:558–566.

James G, Garcia Sanchez JJ, Carrero JJ, Kumar S, Pecoits-Filho R, Heerspink HJL, et al. Low adherence to kidney disease: improving global outcomes 2012 CKD clinical practice guidelines despite clear evidence of utility. Kidney Int Rep 2022; 7:2059–2070.

Alfego D, Ennis J, Gillespie B, Lewis MJ, Montgomery E, Ferre S, et al. Chronic kidney disease testing among at-risk adults in the U.S. remains low: real-world evidence from a national laboratory database. Diabetes Care 2021; 44:2025–2032.

Chu CD, Xia F, Du Y, Singh R, Tuot DS, Lamprea-Montealegre JA, et al. Estimated prevalence and testing for albuminuria in US adults at risk for chronic kidney disease. JAMA Netw Open 2023; 6:e2326230.

Shlipak MG, Tummalapalli SL, Boulware LE, Grams ME, Ix JH, Jha V, et al. The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference. Kidney Int 2021; 99:34–47.

Groehl F, Garreta-Rufas A, Meredith K, Harris J, Rossing P, Hobbs FDR, et al. The drivers of nonadherence to albuminuria testing guidelines and the clinical and economic impact of not identifying chronic kidney disease. Clin Nephrol 2023; 100:145–156.

Abdel-Kader K, Greer RC, Boulware LE, Unruh ML. Primary care physicians’ familiarity, beliefs, and perceived barriers to practice guidelines in nondiabetic CKD: a survey study. BMC Nephrol 2014; 15:64.

Ortiz A, Ferro CJ, Balafa O, Burnier M, Ekart R, Halimi JM, et al. Mineralocorticoid receptor antagonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. Nephrol Dial Transplant 2023; 38:10–25.

Sarafidis P, Ortiz A, Ferro CJ, Halimi JM, Kreutz R, Mallamaci F, et al. Sodium--glucose co-transporter-2 inhibitors for patients with diabetic and nondiabetic chronic kidney disease: a new era has already begun. J Hypertens 2021; 39:1090–1097.

Shirazian S, Grant CD, Mujeeb S, Sharif S, Kumari P, Bhagat M, et al. Underprescription of renin-angiotensin system blockers in moderate to severe chronic kidney disease. Am J Med Sci 2015; 349:510–515.

Rossignol P, Massy ZA, Azizi M, Bakris G, Ritz E, Covic A, et al. The double challenge of resistant hypertension and chronic kidney disease. Lancet 2015; 386:1588–1598.

An J, Kurella Tamura M, Odden MC, Ni L, Thomas IC, Montez-Rath ME, et al. Prevalence of apparent treatment-resistant hypertension in chronic kidney disease in two large US healthcare systems. Clin J Am Soc Nephrol 2022; 17:1457–1466.

Halimi JM, de Freminville JB, Gatault P, Bisson A, Sautenet B, Maisons V, et al. Characteristics and prognosis of patients with hypertensive encephalopathy: a French Nationwide Cohort Study. Hypertension 2023; 80:1716–1727.

Halimi JM, de Freminville JB, Gatault P, Bisson A, Gueguen J, Goin N, et al. Long-term impact of cardiorenal syndromes on major outcomes based on their chronology: a comprehensive French nationwide cohort study. Nephrol Dial Transplant 2022; 37:2386–2397.

Boulestreau R, Lorthioir A, Persu A, Sarafidis P, Cremer A, Tharaux PL, et al. Revisiting malignant hypertension: rationale and design of the ‘HAMA cohort’, on behalf of the ESH working group ‘hypertension and the kidney’. J Hypertens 2023; 41:453–458.

Weber T, Amar J, de Backer T, Burkard T, van der Giet M, Gosse P, et al. Covid-19 associated reduction in hypertension-related diagnostic and therapeutic procedures in Excellence Centers of the European Society of Hypertension. Blood Press 2022; 31:71–79.

Burnier M, Prejbisz A, Weber T, Azizi M, Cunha V, Versmissen J, et al. Hypertension healthcare professional beliefs and behaviour regarding patient medication adherence: a survey conducted among European Society of Hypertension Centres of Excellence. Blood Press 2021; 30:282–290.

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