Brucellosis is one of the most important zoonoses worldwide, primarily affecting livestock but also posing a serious threat to public health. The major Brucella species are known to cause a feverish disease in humans with various clinical signs. These classical Brucella species are (re-)emerging, but also novel strains and species, some of them transmitted from rodents, can be associated with human infections. As a result of our review on rodent-borne brucellosis, we emphasise the need for more comprehensive surveillance of Brucella and especially Brucella microti in rodent populations and call for further research targeting the ecological persistence of rodent-associated Brucella species in the environment, their epizootic role in wild rodents and their virulence and pathogenicity for wildlife.

Department 1 Infectious Diseases Robert Koch Institute Berlin Germany

Department of Bacteriology Animal and Plant Health Agency Weybridge UK

Department of Experimental Biology Masaryk University Brno Czech Republic

Institute of Vertebrate Biology Czech Academy of Sciences Brno Czech Republic

KB One Health Fort Collins Colorado USA

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About, F. , Pastre T., Boutru M., et al. 2023. “Novel Species of PubMed DOI PMC

Ackelsberg, J. , Liddicoat A., Burke T., et al. 2020. “ PubMed DOI PMC

Al Dahouk, S. , Hofer E., Tomaso H, et al. 2012. “Intraspecies Biodiversity of the Genetically Homologous Species PubMed DOI PMC

Al Dahouk, S. , Köhler S., Occhialini A., et al. 2017. “ PubMed DOI PMC

Audic, S. , Lescot M., Claverie J. M., and Scholz H. C.. 2009. “ PubMed DOI PMC

Bai, Y. , Urushadze L., Osikowicz L., et al. 2017. “Molecular Survey of Bacterial Zoonotic Agents in Bats From the Country of Georgia (Caucasus).” PLoS One 12: e0171175. 10.1371/journal.pone.0171175. PubMed DOI PMC

Beal, G. A. , Lewis R. E., McCullough N. B., and Claflin R. M.. 1959. “Experimental Infection of Swine With PubMed

Boeer, W. J. , Crawford R. P., Hidalgo R. J., and Robinson R. M.. 1980. “Small Mammals and White‐Tailed Deer as Possible Reservoir Hosts of PubMed DOI

Brangsch, H. , Horstkotte M. A., and Melzer F.. 2023. “Genotypic Peculiarities of a Human Brucellosis Case Caused by PubMed DOI PMC

Cameron, H. S. , and Meyer M. E.. 1958. “Metabolic Studies on PubMed DOI PMC

Chakma, S. , Picard J., Duffy R., Constantinoiu C., and Gummow B.. 2017. “A Survey of Zoonotic Pathogens Carried by Non‐Indigenous Rodents at the Interface of the Wet Tropics of North Queensland, Australia.” Transboundary and Emerging Diseases 64: 185–64193. 10.1111/tbed.12360. PubMed DOI

Cook, I. , Campbell R. W., and Barrow G.. 1966. “Brucellosis in North Queensland Rodents.” Australian Veterinary Journal 42: 5–8. 10.1111/j.1751-0813.1966.tb04603.x. PubMed DOI

Corbel, M. J. 1984. “International Committee on Systematic Bacteriology Subcommittee on Taxonomy of PubMed DOI

Damiano, M. A. , Bastianelli D., Al Dahouk S., et al. 2015. “Glutamate Decarboxylase‐Dependent Acid Resistance in PubMed DOI PMC

De, B. K. , Stauffer L., Koylass M. S., et al. 2008. “Novel PubMed DOI PMC

Dranovskaia, E. A. , Malikov V. E., and Grekova N. A.. 1983. “Izuchenie Biologicheskikh i Fiziko‐Khimicheskikh svoĭstv Brutsell, Vydelennykh Ot Myshevidnykh Gryzunov [Biological and Physicochemical Properties of PubMed

Dushina, O. P. , Mitrofanova L. I., Chudentsova E. N., and Savchenko N. T.. 1964. “A Case of Isolation of Atypical PubMed

Eisenberg, T. , Hamann H. P., Kaim U., et al. 2012. “Isolation of Potentially Novel PubMed DOI PMC

Eisenberg, T. , Riße K., Schauerte N., Geiger C., Blom J., and Scholz H. C.. 2017. “Isolation of a Novel 'Atypical' PubMed DOI

Eisenberg, T. , Schlez K., Fawzy A., et al. 2020. “Expanding the Host Range: Infection of a Reptilian Host ( PubMed DOI PMC

El‐Sayed, A. , and Awad W.. 2018. “Brucellosis: Evolution and Expected Comeback.” International Journal of Veterinary Science and Medicine 6: 31–35. 10.1016/j.ijvsm.2018.01.008. PubMed DOI PMC

European Centre for Disease Prevention and Control . 2023. “Brucellosis.” In ECDC. Annual Epidemiological Report for 2021. Stockholm: ECDC.

Fischer, D. , Lorenz N., Heuser W., Kämpfer P., Scholz H. C., and Lierz M.. 2012. “Abscesses Associated With PubMed DOI

Foster, G. , Osterman B. S., Godfroid J. I., and Cloeckaert A.. 2007. “ PubMed DOI

Gibby, I. W. , and Gibby A. M.. 1965. “Host‐Parasite Relationships With PubMed DOI PMC

González‐Espinoza, G. , Arce‐Gorvel V., Mémet S., and Gorvel J. P.. 2021. “ PubMed DOI PMC

Guzmán‐Verri, C. , Suárez‐Esquivel M., Ruíz‐Villalobos N., et al. 2019. “Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth PubMed DOI PMC

Hammerl, J. A. , Ulrich R. G., Imholt C., et al. 2017. “Molecular Survey on Brucellosis in Rodents and Shrews—Natural Reservoirs of Novel PubMed DOI

Hanna, N. , Jiménez de Bagüés M. P., Ouahrani‐Bettache S., El Yakhlifi Z., Köhler S., and Occhialini A.. 2011. “The virB Operon Is Essential for Lethality of PubMed DOI

Heisch, R. B. , Cooke E. R., Harvey A. E., and De Souza F.. 1963. “The Isolation of PubMed

Hofer, E. , Revilla‐Fernández S., Al Dahouk S., et al. 2012. “A Potential Novel PubMed DOI

Hördt, A. , López M. G., Meier‐Kolthoff J. P., et al. 2020. “Analysis of 1,000+ Type‐Strain Genomes Substantially Improves Taxonomic Classification of PubMed DOI PMC

Hubálek, Z. , Křivanová A., Nesvadbová J., and Rudolf I.. 2023. “Zoonotic Potential of PubMed DOI

Hubálek, Z. , Scholz H. C., Sedláček I., Melzer F., Sanogo Y. O., and Nesvadbová J.. 2007. “Brucellosis of the Common Vole ( PubMed DOI

Jaÿ, M. , Freddi L., Mick V., et al. 2020. “ PubMed DOI

Jaÿ, M. , Girault G., Perrot L., et al. 2018. “Phenotypic and Molecular Characterization of PubMed DOI PMC

Jiménez de Bagüés, M. P. , de Martino A., Quintana J. F., Alcaraz A., and Pardo J.. 2011. “Course of Infection With the Emergent Pathogen PubMed DOI PMC

Jiménez de Bagüés, M. P. , Ouahrani‐Bettache S., Quintana J. F., et al. 2010. “The New Species PubMed DOI

Kang, Y. S. , Brown D. A., and Kirby J. E.. 2019. “ PubMed DOI PMC

Kang, Y. S. , and Kirby J. E.. 2017. “Promotion and Rescue of Intracellular PubMed DOI PMC

Kimura, M. , Une Y., Suzuki M., Park E., Imaoka K., and Morikawa S.. 2017. “Isolation of PubMed DOI

Kolbabová, J. , Havlasová J., and Veleba J.. 2001. “Brucellosis.” Klinická Mikrobiologie infekční lékařství 7: 210–213. (Czech).

Liamkin, G. I. , Taran I. F., Safronova V. M., Tikhenko N. I., and Shiranovich M. P.. 1983. “Taxonomic Position and Ecology of the Causative Agent of Brucellosis Isolated From Murine Rodents in Regions of the Northern Foothills of the Greater Caucasus. II. The Ecological and Pathogenetic Characteristics of PubMed

Liamkin, G. I. , Tiumentseva I. S., and Afanas'ev E. N.. 1983. “Taxonomy and Ecology of Brucellosis Pathogens Isolated From Muridae in the Northern Foothills of the Caucasus Mountains. I. Cultural and Biochemical Properties of PubMed

Mand'áková, Z. 2024. “Brucelóza.” SZÚ. http://www.szu.cz/tema/prevence/bruceloza‐1 [online].

McDonald, W. L. , Jamaludin R., Mackereth G., et al. 2006. “Characterization of a PubMed DOI PMC

Meyer, M. E. 1976. “Evolution and Taxonomy in the Genus PubMed

Moore, C. G. , and Schnurrenberger P. R.. 1981. “A Review of Naturally Occurring PubMed

Moreno, E. , Blasco J. M., Letesson J. J., Gorvel J. P., and Moriyón I.. 2022. “Pathogenicity and Its Implications in Taxonomy: The PubMed DOI PMC

Moreno, E. , Middlebrook E. A., Altamirano‐Silva P., et al. 2023. “If You're Not Confused, You're Not Paying Attention: PubMed DOI PMC

Morris, J. G., Jr. , and Southwick F. S.. 2010. “ PubMed DOI

Mühldorfer, K. , Wibbelt G., Szentiks C. A., et al. 2017. “The Role of ‘atypical’ PubMed DOI

Occhialini, A. , Hofreuter D., Ufermann C. M., Al Dahouk S., and Köhler S.. 2022. “The Retrospective on Atypical PubMed DOI PMC

Olsen, S. C. , and Palmer M. V.. 2014. “Advancement of Knowledge of PubMed DOI

Ouahrani‐Bettache, S. , Jiménez De Bagüés M. P., De La Garza J., et al. 2019. “Lethality of PubMed DOI PMC

Pappas, G. 2010. “The Changing PubMed DOI

Repina, L. P. , Nikulina A. I., and Kosilov I. A.. 1993. “A Case of Human Infection With Brucellosis From a Cat.” Zhurnal Mikrobiologie Epidemiologie Immunobiologie 4: 66–68. PubMed

Rónai, Z. , Kreizinger Z., Dán Á., et al. 2015. “First Isolation and Characterization of PubMed DOI PMC

Rouzic, N. , Desmier L., Cariou M. E., et al. 2021. “First Case of Brucellosis Caused by an Amphibian‐Type PubMed DOI

Scholz, H. C. , Hubálek Z., Nesvadbová J., et al. 2008a. “Isolation of PubMed DOI PMC

Scholz, H. C. , Hubálek Z., Sedláček I., et al. 2008b. “ PubMed DOI

Scholz, H. C. , Mühldorfer K., Shilton C., et al. 2016a. “The Change of a Medically Important Genus: Worldwide Occurrence of Genetically Diverse Novel PubMed DOI PMC

Scholz, H. C. , Nöckler K., Göllner C., et al. 2010. “ PubMed DOI

Scholz, H. C. , Revilla‐Fernández S., Al Dahouk S., et al. 2016b. “ PubMed DOI

Sohn, A. H. , Probert W. S., Glaser C. A., et al. 2003. “Human Neurobrucellosis With Intracerebral Granuloma Caused by a Marine Mammal PubMed DOI PMC

Soler‐Lloréns, P. F. , Quance C. R., Lawhon S. D., et al. 2016. “A PubMed DOI PMC

Stoenner, H. G. , and Lackman D. B.. 1957. “A New Species of PubMed

Suárez‐Esquivel, M. , Ruiz‐Villalobos N., Jiménez‐Rojas C., et al. 2017. “ PubMed DOI PMC

Tiller, R. V. , Gee J. E., Frace M. A., et al. 2010a. “Characterization of Novel PubMed DOI PMC

Tiller, R. V. , Gee J. E., Lonsway D. R., et al. 2010b. “Identification of an Unusual PubMed DOI PMC

Truong, L. Q. , Kim J. T., Yoon B. I., Her M., Jung S. C., and Hahn T. W.. 2011. “Epidemiological Survey for PubMed DOI

Vergnaud, G. , Zygmunt M. S., Ashford R. T., Whatmore A. M., and Cloeckaert A.. 2024. “Genomic Diversity and Zoonotic Potential of PubMed DOI PMC

Vershilova, P. A. , Liamkin G. I., Malikov V. E., Dranovskaya E. A., and Taran I. F.. 1983. “ DOI

Villalobos‐Vindas, J. M. , Amuy E., Barquero‐Calvo E., et al. 2017. “Brucellosis Caused by the Wood Rat Pathogen PubMed DOI PMC

Waldrop, S. G. , and Sriranganathan N.. 2019. “Intracellular Invasion and Survival of PubMed DOI PMC

Wattam, A. R. , Foster J. T., Mane S. P., et al. 2014. “Comparative Phylogenomics and Evolution of the Brucellae Reveal a Path to Virulence.” Journal of Bacteriology 196, no. 5: 920–930. 10.1128/jb.01091-13. PubMed DOI PMC

Wattam, A. R. , Inzana T. J., Williams K. P., et al. 2012. “Comparative Genomics of Early‐Diverging PubMed DOI PMC

Whatmore, A. M. 2009. “Current Understanding of the Genetic Diversity of PubMed DOI

Whatmore, A. M. , Davison N., Cloeckaert A., et al. 2014. “ PubMed DOI PMC

Whatmore, A. M. , Dawson C. E., Groussaud P., et al. 2008. “Marine Mammal PubMed DOI PMC

Whatmore, A. M. , and Foster J. T.. 2021. “Emerging Diversity and Ongoing Expansion of the Genus PubMed DOI

Zhang, N. , Huang D., Wu W., et al. 2018. “Animal Brucellosis Control or Eradication Programs Worldwide: A Systematic Review of Experiences and Lessons Learned.” Preventive Veterinary Medicine 160: 105–115. 10.1016/j.prevetmed.2018.10.002. PubMed DOI

Zheng, R. , Xie S., Lu X., et al. 2018. “A Systematic Review and Meta‐Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.” BioMed Research International 2018: 5712920. 10.1155/2018/5712920. PubMed DOI PMC

Zygmunt, M. S. , Jacques I., Bernardet N., and Cloeckaert A.. 2012. “Lipopolysaccharide Heterogeneity in the Atypical Group of Novel Emerging PubMed DOI PMC