High-Temperature Requirement A Serine Peptidase 2 [serinová proteasa HTRA2]

topical
Terms

proteasa HtrA2
proteáza HtrA2
serinová proteáza HTRA2
serinová proteáza Omi

 

HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Serine Protease HTRA2
Serine Protease Omi

Persistent link   https://www.medvik.cz/link/D000074923
Definition

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

DUI
D000074923 MeSH Browser
CUI
M000628721
History note
2018 (2000)
Public note
2018; HIGH-TEMPERATURE REQUIREMENT A SERINE PEPTIDASE 2 was indexed under SERINE ENDOPEPTIDASES and MITOCHONDRIAL PROTEINS 2000-2017

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 559
D08.811.277.656.300 Endopeptidases 211
D08.811.277.656.300.760 Serine Endopeptidases 138
D08.811.277.656.300.760.030 Acrosin 14
D08.811.277.656.300.760.066 Cathepsin G 4
D08.811.277.656.300.760.103 Chymases 5
D08.811.277.656.300.760.176 Chymotrypsin 133
D08.811.277.656.300.760.198 Complement Factor B 3
D08.811.277.656.300.760.200 Complement Factor D 5
D08.811.277.656.300.760.210 Complement Factor I
D08.811.277.656.300.760.247 Endopeptidase K 7
D08.811.277.656.300.760.284 Enteropeptidase 3
D08.811.277.656.300.760.300 Factor VIIa 110
D08.811.277.656.300.760.310 Factor IXa 6
D08.811.277.656.300.760.315 Factor Xa 189
D08.811.277.656.300.760.320 Factor XIa 7
D08.811.277.656.300.760.324 Factor XIIa 2
D08.811.277.656.300.760.330 Fibrinolysin 44
D08.811.277.656.300.760.353 Furin 2
D08.811.277.656.300.760.397 Granzymes 11
D08.811.277.656.300.760.420 High-Temperature Requirement A Serine Peptidase 1 1
D08.811.277.656.300.760.431 High-Temperature Requirement A Serine Peptidase 2
D08.811.277.656.300.760.442 Kallikreins 39
D08.811.277.656.300.760.471 Lactoferrin 32
D08.811.277.656.300.760.501 Mannose-Binding Protein-Associated Serine Proteases 2
D08.811.277.656.300.760.530 Myeloblastin 8
D08.811.277.656.300.760.560 Pancreatic Elastase 93
D08.811.277.656.300.760.635 Plasminogen Activators 56
D08.811.277.656.300.760.637 Prolyl Oligopeptidases 3
D08.811.277.656.300.760.638 Pronase 4
D08.811.277.656.300.760.640 Proprotein Convertase 1 4
D08.811.277.656.300.760.646 Proprotein Convertase 2
D08.811.277.656.300.760.648 Proprotein Convertase 5
D08.811.277.656.300.760.718 Proprotein Convertase 9 269
D08.811.277.656.300.760.753 Reelin Protein
D08.811.277.656.300.760.787 Subtilisins 7
D08.811.277.656.300.760.855 Thrombin 228
D08.811.277.656.300.760.875 Tissue Plasminogen Activator 237
D08.811.277.656.300.760.895 Trypsin 257
D08.811.277.656.300.760.902 Tryptases 35
D08.811.277.656.300.760.910 Urokinase-Type Plasminogen Activator 61
D08.811.277.656.300.760.955 Venombin A 1
D08.811.277.656.959 Serine Proteases 21
D08.811.277.656.959.350 Serine Endopeptidases 138
D08.811.277.656.959.350.030 Acrosin 14
D08.811.277.656.959.350.066 Cathepsin G 4
D08.811.277.656.959.350.103 Chymases 5
D08.811.277.656.959.350.176 Chymotrypsin 133
D08.811.277.656.959.350.198 Complement Factor B 3
D08.811.277.656.959.350.200 Complement Factor D 5
D08.811.277.656.959.350.210 Complement Factor I
D08.811.277.656.959.350.247 Endopeptidase K 7
D08.811.277.656.959.350.284 Enteropeptidase 3
D08.811.277.656.959.350.300 Factor VIIa 110
D08.811.277.656.959.350.310 Factor IXa 6
D08.811.277.656.959.350.315 Factor Xa 189
D08.811.277.656.959.350.320 Factor XIa 7
D08.811.277.656.959.350.324 Factor XIIa 2
D08.811.277.656.959.350.330 Fibrinolysin 44
D08.811.277.656.959.350.353 Furin 2
D08.811.277.656.959.350.397 Granzymes 11
D08.811.277.656.959.350.420 High-Temperature Requirement A Serine Peptidase 1 1
D08.811.277.656.959.350.431 High-Temperature Requirement A Serine Peptidase 2
D08.811.277.656.959.350.442 Kallikreins 39
D08.811.277.656.959.350.471 Lactoferrin 32
D08.811.277.656.959.350.501 Mannose-Binding Protein-Associated Serine Proteases 2
D08.811.277.656.959.350.530 Myeloblastin 8
D08.811.277.656.959.350.560 Pancreatic Elastase 93
D08.811.277.656.959.350.635 Plasminogen Activators 56
D08.811.277.656.959.350.638 Pronase 4
D08.811.277.656.959.350.640 Proprotein Convertase 1 4
D08.811.277.656.959.350.646 Proprotein Convertase 2
D08.811.277.656.959.350.648 Proprotein Convertase 5
D08.811.277.656.959.350.718 Proprotein Convertase 9 269
D08.811.277.656.959.350.753 Reelin Protein
D08.811.277.656.959.350.787 Subtilisins 7
D08.811.277.656.959.350.855 Thrombin 228
D08.811.277.656.959.350.875 Tissue Plasminogen Activator 237
D08.811.277.656.959.350.895 Trypsin 257
D08.811.277.656.959.350.902 Tryptases 35
D08.811.277.656.959.350.910 Urokinase-Type Plasminogen Activator 61
D08.811.277.656.959.350.955 Venombin A 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.075 Apoptosis Regulatory Proteins 78
D12.776.476.075.311 Apoptosis Inducing Factor 10
D12.776.476.075.323 Bcl-2-Like Protein 11 5
D12.776.476.075.335 Beclin-1 3
D12.776.476.075.358 CARD Signaling Adaptor Proteins 7
D12.776.476.075.405 Caspases 157
D12.776.476.075.413 DCC Receptor
D12.776.476.075.421 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.075.429 High-Temperature Requirement A Serine Peptidase 2
D12.776.476.075.437 Inhibitor of Apoptosis Proteins 29
D12.776.476.075.718 Proto-Oncogene Proteins c-bcl-2 147
D12.776.575 Mitochondrial Proteins 208
D12.776.575.093 Aldehyde Dehydrogenase, Mitochondrial 5
D12.776.575.140 ATPase Inhibitory Protein
D12.776.575.186 Creatine Kinase, Mitochondrial Form 3
D12.776.575.280 DNA Polymerase gamma 3
D12.776.575.374 Endopeptidase Clp
D12.776.575.562 Ferrochelatase 11
D12.776.575.609 Frataxin 2
D12.776.575.656 High-Temperature Requirement A Serine Peptidase 2
D12.776.575.750 Mitochondrial Membrane Transport Proteins 35
D12.776.575.758 Mitochondrial Processing Peptidase
D12.776.575.765 Mitochondrial Trifunctional Protein 2
D12.776.575.781 Nucleoside Diphosphate Kinase D
D12.776.575.812 Peroxiredoxin III 2
D12.776.575.844 Prohibitins 1
D12.776.575.875 Sirtuin 3 5
D12.776.705 Parkinson Disease Associated Proteins
D12.776.705.500 alpha-Synuclein 56
D12.776.705.625 High-Temperature Requirement A Serine Peptidase 2
D12.776.705.750 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 2
D12.776.705.875 Protein Deglycase DJ-1 3
D12.776.705.937 Ubiquitin Thiolesterase 27

HTRA2 protein, human Chemical MeSH Browser

HtrA2 protein, Drosophila Chemical MeSH Browser

Htra2 protein, mouse Chemical MeSH Browser

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