protoonkogenní proteiny c-abl [Proto-Oncogene Proteins c-abl]

tematický
7
Termíny

abl Proto-Oncogene Products
abl Proto-Oncogene Proteins
c-abl Proteins
Proto-Oncogene Proteins abl

Perzistentní odkaz   https://www.medvik.cz/link/D016315
Definice

Nereceptorové tyrosinkinázy kódované geny c-abl. Jsou distribuovány jak v cytoplazmě, tak v jádře. c-Abl hraje roli v normální hematopoéze, zejména v myeloidní linii. Onkogenní transformace c-abl vzniká při odstranění specifických N-koncových aminokyselin, čímž se kináza uvolní z negativní regulace.

Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

DUI
D016315 MeSH Prohlížeč
CUI
M0024934
Předchozí užití
Proto-Oncogene Proteins (1986-1990); Neoplasm Proteins (1983-1985)
Historická pozn.
91
Veřejná pozn.
91

D Chemikálie a léčiva
D08.811 enzymy 1 547
D08.811.913 transferasy 72
D08.811.913.696 fosfotransferasy 69
D08.811.913.696.620.682 proteinkinasy 248
D08.811.913.696.620.682.725 tyrosinkinasy 620
D08.811.913.696.620.682.725.025 proteinkinasa BTK 47
D08.811.913.696.620.682.725.037 kinasy Dyrk
D08.811.913.696.620.682.725.049 fokální adhezní tyrosinkinasy 9
D08.811.913.696.620.682.725.124 Janus kinasy 90
D08.811.913.696.620.682.725.200 mitogenem aktivované proteinkinasy kinas 40
D08.811.913.696.620.682.725.300 protoonkogenní proteiny c-fes
D08.811.913.696.620.682.725.400 tyrosinkinasové receptory 148
D08.811.913.696.620.682.725.500 protoonkogenní proteiny c-abl 7
D08.811.913.696.620.682.725.500.500 bcr-abl fúzní proteiny 235
D08.811.913.696.620.682.725.650 kinasa Syk 11
D08.811.913.696.620.682.725.800 skupina kinas odvozených od src-genu 50
D08.811.913.696.620.682.725.900 protein-tyrosinkináza ZAP-70 21
D12.776 proteiny 2 575
D12.776.476.568 tyrosinkinasy 620
D12.776.476.568.025 proteinkinasa BTK 47
D12.776.476.568.037 kinasy Dyrk
D12.776.476.568.124 Janus kinasy 90
D12.776.476.568.400 tyrosinkinasové receptory 148
D12.776.476.568.500 protoonkogenní proteiny c-abl 7
D12.776.476.568.500.500 bcr-abl fúzní proteiny 235
D12.776.476.568.650 kinasa Syk 11
D12.776.476.568.900 protein-tyrosinkináza ZAP-70 21
D12.776.624 nádorové proteiny 411
D12.776.624.664 onkogenní proteiny 125
D12.776.624.664.700 protoonkogenní proteiny 263
D12.776.624.664.700.013 tyrozinkinasový receptor AXL
D12.776.624.664.700.025 protein BCL2L11 5
D12.776.624.664.700.037 tyrosinkinasa c-Mer 2
D12.776.624.664.700.049 chemokin CXCL1 7
D12.776.624.664.700.100 cyklin D1 86
D12.776.624.664.700.110 fibroblastový růstový faktor 4 2
D12.776.624.664.700.112 fibroblastový růstový faktor 6
D12.776.624.664.700.114 tyrosinkinasa 3 podobná fms 49
D12.776.624.664.700.117 Janus kinasa 2 79
D12.776.624.664.700.119 protein KRIT1
D12.776.624.664.700.120 KLF6 1
D12.776.624.664.700.123 lipokalin-2 21
D12.776.624.664.700.129 protein MDS1 and EVI1 complex locus 2
D12.776.624.664.700.130 homolog 2 proteinu MutS 17
D12.776.624.664.700.148 protoonkogenní protein MLL 39
D12.776.624.664.700.158 protoonkogen n-myc 9
D12.776.624.664.700.165 protein bcl-3
D12.776.624.664.700.166 protoonkogen Mas 2
D12.776.624.664.700.167 protoonkogenní proteiny c-abl 7
D12.776.624.664.700.168 protoonkogenní proteiny c-akt 116
D12.776.624.664.700.169 protoonkogenní proteiny c-bcl-2 147
D12.776.624.664.700.170 protoonkogenní proteiny c-bcl-6 3
D12.776.624.664.700.171 protoonkogenní proteiny c-bcr 19
D12.776.624.664.700.172 protoonkogenní proteiny c-cbl 5
D12.776.624.664.700.174 protoonkogenní proteiny c-crk 1
D12.776.624.664.700.175 protoonkogenní proteiny c-ets 19
D12.776.624.664.700.177 protoonkogenní proteiny c-fes
D12.776.624.664.700.179 protoonkogenní proteiny c-fos 61
D12.776.624.664.700.180 protoonkogenní proteiny c-fyn 4
D12.776.624.664.700.181 protoonkogenní proteiny c-hck 1
D12.776.624.664.700.182 protoonkogenní proteiny c-jun 17
D12.776.624.664.700.183 protoonkogenní proteiny c-kit 77
D12.776.624.664.700.184 protoonkogenní proteiny c-maf 1
D12.776.624.664.700.185 protoonkogenní proteiny c-mdm2 65
D12.776.624.664.700.186 protoonkogenní proteiny c-met 30
D12.776.624.664.700.187 protoonkogenní proteiny c-mos 2
D12.776.624.664.700.188 protoonkogenní proteiny c-myb 30
D12.776.624.664.700.189 protoonkogenní proteiny c-myc 66
D12.776.624.664.700.191 protoonkogenní proteiny c-pim-1 1
D12.776.624.664.700.192 protoonkogenní proteiny c-rel 2
D12.776.624.664.700.194 protoonkogenní proteiny c-ret 42
D12.776.624.664.700.195 protoonkogenní proteiny c-sis 3
D12.776.624.664.700.198 protoonkogenní proteiny c-vav 4
D12.776.624.664.700.199 protoonkogenní proteiny c-yes 1
D12.776.624.664.700.200 protoonkogenní proteiny p21(ras) 71
D12.776.624.664.700.202 protoonkogenní proteiny pp60(c-src) 7
D12.776.624.664.700.204 raf kinasy 70
D12.776.624.664.700.642 receptor erbB-2 584
D12.776.624.664.700.790 receptor erbB-3 9
D12.776.624.664.700.791 receptor ErbB-4
D12.776.624.664.700.815 receptor Notch4
D12.776.624.664.700.830 receptory thyreoidních hormonů 40
D12.776.624.664.700.913 protein EWS vázající RNA 15
D12.776.624.664.700.915 protein FUS vázající RNA 6
D12.776.624.664.700.936 protein RUNX1T1
D12.776.624.664.700.957 stathmin 4
D12.776.624.664.700.960 transkripční faktor TAL1
D12.776.624.664.700.962 protein Wnt 5a 5
D12.776.624.664.700.967 protein Wnt1 4
D12.776.624.664.700.978 protein Wnt2
D12.776.624.664.700.989 protein Gli1 7