Proto-Oncogene Proteins c-abl [protoonkogenní proteiny c-abl]

topical
7
Terms

abl Proto-Oncogene Products
abl Proto-Oncogene Proteins
c-abl Proteins
Proto-Oncogene Proteins abl

Persistent link   https://www.medvik.cz/link/D016315
Definition

Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

DUI
D016315 MeSH Browser
CUI
M0024934
Previous indexing
Proto-Oncogene Proteins (1986-1990); Neoplasm Proteins (1983-1985)
History note
91
Public note
91

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors 1
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis 1
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 3
HI
history
IM
immunology 1
IP
isolation & purification
ME
metabolism 1
PK
pharmacokinetics
PD
pharmacology
PH
physiology 1
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 1
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases 620
D08.811.913.696.620.682.725.025 Agammaglobulinaemia Tyrosine Kinase 48
D08.811.913.696.620.682.725.037 Dyrk Kinases
D08.811.913.696.620.682.725.049 Focal Adhesion Protein-Tyrosine Kinases 9
D08.811.913.696.620.682.725.124 Janus Kinases 90
D08.811.913.696.620.682.725.200 Mitogen-Activated Protein Kinase Kinases 41
D08.811.913.696.620.682.725.300 Proto-Oncogene Proteins c-fes
D08.811.913.696.620.682.725.400 Receptor Protein-Tyrosine Kinases 154
D08.811.913.696.620.682.725.500 Proto-Oncogene Proteins c-abl 7
D08.811.913.696.620.682.725.500.500 Fusion Proteins, bcr-abl 238
D08.811.913.696.620.682.725.650 Syk Kinase 11
D08.811.913.696.620.682.725.800 src-Family Kinases 50
D08.811.913.696.620.682.725.900 ZAP-70 Protein-Tyrosine Kinase 21
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.568 Protein-Tyrosine Kinases 620
D12.776.476.568.025 Agammaglobulinaemia Tyrosine Kinase 48
D12.776.476.568.037 Dyrk Kinases
D12.776.476.568.049 Focal Adhesion Protein-Tyrosine Kinases 9
D12.776.476.568.124 Janus Kinases 90
D12.776.476.568.200 Mitogen-Activated Protein Kinase Kinases 41
D12.776.476.568.300 Proto-Oncogene Proteins c-fes
D12.776.476.568.400 Receptor Protein-Tyrosine Kinases 154
D12.776.476.568.500 Proto-Oncogene Proteins c-abl 7
D12.776.476.568.500.500 Fusion Proteins, bcr-abl 238
D12.776.476.568.650 Syk Kinase 11
D12.776.476.568.800 src-Family Kinases 50
D12.776.476.568.900 ZAP-70 Protein-Tyrosine Kinase 21
D12.776.624 Neoplasm Proteins 412
D12.776.624.664 Oncogene Proteins 125
D12.776.624.664.700 Proto-Oncogene Proteins 263
D12.776.624.664.700.013 Axl Receptor Tyrosine Kinase
D12.776.624.664.700.025 Bcl-2-Like Protein 11 5
D12.776.624.664.700.037 c-Mer Tyrosine Kinase 2
D12.776.624.664.700.049 Chemokine CXCL1 7
D12.776.624.664.700.100 Cyclin D1 86
D12.776.624.664.700.110 Fibroblast Growth Factor 4 2
D12.776.624.664.700.112 Fibroblast Growth Factor 6
D12.776.624.664.700.114 fms-Like Tyrosine Kinase 3 49
D12.776.624.664.700.117 Janus Kinase 2 79
D12.776.624.664.700.119 KRIT1 Protein
D12.776.624.664.700.120 Kruppel-Like Factor 6 1
D12.776.624.664.700.123 Lipocalin-2 21
D12.776.624.664.700.128 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) 10
D12.776.624.664.700.129 MDS1 and EVI1 Complex Locus Protein 2
D12.776.624.664.700.130 MutS Homolog 2 Protein 17
D12.776.624.664.700.148 Myeloid-Lymphoid Leukemia Protein 39
D12.776.624.664.700.158 N-Myc Proto-Oncogene Protein 9
D12.776.624.664.700.163 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.624.664.700.165 B-Cell Lymphoma 3 Protein
D12.776.624.664.700.166 Proto-Oncogene Mas 2
D12.776.624.664.700.167 Proto-Oncogene Proteins c-abl 7
D12.776.624.664.700.168 Proto-Oncogene Proteins c-akt 117
D12.776.624.664.700.169 Proto-Oncogene Proteins c-bcl-2 147
D12.776.624.664.700.170 Proto-Oncogene Proteins c-bcl-6 3
D12.776.624.664.700.171 Proto-Oncogene Proteins c-bcr 19
D12.776.624.664.700.172 Proto-Oncogene Proteins c-cbl 5
D12.776.624.664.700.174 Proto-Oncogene Proteins c-crk 1
D12.776.624.664.700.175 Proto-Oncogene Proteins c-ets 19
D12.776.624.664.700.177 Proto-Oncogene Proteins c-fes
D12.776.624.664.700.179 Proto-Oncogene Proteins c-fos 61
D12.776.624.664.700.180 Proto-Oncogene Proteins c-fyn 4
D12.776.624.664.700.181 Proto-Oncogene Proteins c-hck 1
D12.776.624.664.700.182 Proto-Oncogene Proteins c-jun 17
D12.776.624.664.700.183 Proto-Oncogene Proteins c-kit 77
D12.776.624.664.700.184 Proto-Oncogene Proteins c-maf 1
D12.776.624.664.700.185 Proto-Oncogene Proteins c-mdm2 65
D12.776.624.664.700.186 Proto-Oncogene Proteins c-met 30
D12.776.624.664.700.187 Proto-Oncogene Proteins c-mos 2
D12.776.624.664.700.188 Proto-Oncogene Proteins c-myb 30
D12.776.624.664.700.189 Proto-Oncogene Proteins c-myc 66
D12.776.624.664.700.191 Proto-Oncogene Proteins c-pim-1 1
D12.776.624.664.700.192 Proto-Oncogene Proteins c-rel 2
D12.776.624.664.700.194 Proto-Oncogene Proteins c-ret 42
D12.776.624.664.700.195 Proto-Oncogene Proteins c-sis 3
D12.776.624.664.700.198 Proto-Oncogene Proteins c-vav 4
D12.776.624.664.700.199 Proto-Oncogene Proteins c-yes 1
D12.776.624.664.700.200 Proto-Oncogene Proteins p21(ras) 71
D12.776.624.664.700.202 Proto-Oncogene Proteins pp60(c-src) 7
D12.776.624.664.700.204 raf Kinases 70
D12.776.624.664.700.642 Receptor, ErbB-2 585
D12.776.624.664.700.790 Receptor, ErbB-3 9
D12.776.624.664.700.791 Receptor, ErbB-4
D12.776.624.664.700.792 Receptor, Fibroblast Growth Factor, Type 3 27
D12.776.624.664.700.800 Receptor, Macrophage Colony-Stimulating Factor 1
D12.776.624.664.700.815 Receptor, Notch4
D12.776.624.664.700.830 Receptors, Thyroid Hormone 40
D12.776.624.664.700.913 RNA-Binding Protein EWS 15
D12.776.624.664.700.915 RNA-Binding Protein FUS 6
D12.776.624.664.700.936 RUNX1 Translocation Partner 1 Protein
D12.776.624.664.700.957 Stathmin 4
D12.776.624.664.700.960 T-Cell Acute Lymphocytic Leukemia Protein 1
D12.776.624.664.700.962 Wnt-5a Protein 5
D12.776.624.664.700.967 Wnt1 Protein 4
D12.776.624.664.700.978 Wnt2 Protein
D12.776.624.664.700.989 Zinc Finger Protein GLI1 7

ABL-1 protein, C elegans Chemical MeSH Browser

ABL1 protein, human Chemical MeSH Browser

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