Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

DUI

D017252 MeSH Browser

CUI

M0026174

Previous indexing

Antigens (1983-1984); Antigens, Differentiation, T-Lymphocyte (1988-1992); Antigens, Surface (1983-1987); Receptors, Antigen, T-Cell (1990-1992)

History note

2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92

Public note

2018; see ANTIGENS, CD3 1993-2017; CD3 COMPLEX was indexed under RECEPTORS, ANTIGEN, T-CELL 1990-92; under ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92; under ANTIGENS, SURFACE 1983-87; and under ANTIGENS 1983-84; for T3 ANTIGENS see ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92