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protoonkogenní proteiny c-bcr [Proto-Oncogene Proteins c-bcr]

tematický
19
Termíny

proteiny c-bcr
protoonkogenní proteiny bcr

 

bcr Proto-Oncogene Proteins
Breakpoint Cluster Region Protein
c-bcr Proteins
c-bcr Proto-Oncogene Proteins
Proto-Oncogene Protein bcr
Proto-Oncogene Protein c-bcr

Perzistentní odkaz   https://www.medvik.cz/link/D051562
Definice

Serin-threoninová kináza, která obsahuje domény C2 a PH. Působí také jako protein aktivující GTPázu pro proteiny rac1 a cdc42. Funguje jako negativní regulátor buněčné proliferace a nádorové transformace. U pacientů s leukemií s pozitivním filadelfským chromozomem se běžně spojuje s buněčným proteinem abl, a vytváří tak fúzní proteiny bcr-abl.

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

DUI
D051562 MeSH Prohlížeč
CUI
M0155533
Historická pozn.
2006(1988)
Veřejná pozn.
2006; PROTO-ONCOGENE PROTEIN C-BCR was indexed under PROTEIN-TYROSINE KINASE & PROTO-ONCOGENE PROTEINS 1988-2005

D Chemikálie a léčiva
D08.811 enzymy 1 554
D08.811.913 transferasy 72
D08.811.913.696 fosfotransferasy 69
D08.811.913.696.620.682 proteinkinasy 249
D08.811.913.696.620.682.700 protein-serin-threoninkinasy 274
D08.811.913.696.620.682.700.062 aktivinové receptory 5
D08.811.913.696.620.682.700.074 kinasy AMP aktivovaných proteinkinas 1
D08.811.913.696.620.682.700.085 proteinkinasy aktivované AMP 43
D08.811.913.696.620.682.700.097 ATM protein 92
D08.811.913.696.620.682.700.103 kinasy Aurora 4
D08.811.913.696.620.682.700.108 homolog Atg1 1
D08.811.913.696.620.682.700.109 receptory kostního morfogenetického proteinu 3
D08.811.913.696.620.682.700.125 proteinkinasy závislé na vápníku a kalmodulinu 10
D08.811.913.696.620.682.700.140 kaseinkinasy 1
D08.811.913.696.620.682.700.143 checkpoint kinasa 1 20
D08.811.913.696.620.682.700.145 checkpoint kinasa 2 51
D08.811.913.696.620.682.700.250 proteinkinasa aktivovaná DNA 15
D08.811.913.696.620.682.700.275 kinasy podobné doublecortinu
D08.811.913.696.620.682.700.288 kinasy Dyrk
D08.811.913.696.620.682.700.300 kinasa eIF-2 8
D08.811.913.696.620.682.700.364 kinasy receptorů spřažených s G-proteiny 2
D08.811.913.696.620.682.700.397 kinázy zárodečného centra 2
D08.811.913.696.620.682.700.429 kinasy glykogensynthasy
D08.811.913.696.620.682.700.494 kinasa I-kappa B 9
D08.811.913.696.620.682.700.526 kinázy asociované s receptory interleukinu-1 3
D08.811.913.696.620.682.700.534 LRRK2 4
D08.811.913.696.620.682.700.542 Lim-kinasy 2
D08.811.913.696.620.682.700.559 MAP kinasy kinas (kinas) 48
D08.811.913.696.620.682.700.565 mitogenem aktivované proteinkinasy kinas 42
D08.811.913.696.620.682.700.567 mitogenem aktivované proteinkinasy 101
D08.811.913.696.620.682.700.576 DM-kinasa 2
D08.811.913.696.620.682.700.579 kinasa indukující NF-kappaB 1
D08.811.913.696.620.682.700.581 kinasy NEK 4
D08.811.913.696.620.682.700.586 onkogenní protein v-akt 5
D08.811.913.696.620.682.700.596 p21 aktivované kinasy 9
D08.811.913.696.620.682.700.606 fytochrom A 2
D08.811.913.696.620.682.700.616 polo-like kinasy
D08.811.913.696.620.682.700.626 pozitivní transkripční elongační faktor b 4
D08.811.913.696.620.682.700.646 proteinkinasy řízené prolinem 1
D08.811.913.696.620.682.700.725 proteinkinasa C 139
D08.811.913.696.620.682.700.745 proteinkinasy PDK
D08.811.913.696.620.682.700.750 proteinkinasa D2
D08.811.913.696.620.682.700.755 protoonkogenní proteiny c-akt 123
D08.811.913.696.620.682.700.759 protoonkogenní proteiny c-bcr 19
D08.811.913.696.620.682.700.776 protoonkogenní proteiny c-pim-1 1
D08.811.913.696.620.682.700.783 PDH-kinasa 1
D08.811.913.696.620.682.700.789 TGF-beta receptor I. typu 2
D08.811.913.696.620.682.700.795 TGF-beta receptor II. typu
D08.811.913.696.620.682.700.801 serin-threoninkinasy interagující s receptory 8
D08.811.913.696.620.682.700.814 kinázy asociované s Rho 26
D08.811.913.696.620.682.700.862 kinasy ribozomálního proteinu S6 1
D08.811.913.696.620.682.700.897 serin-threoninkinasa 3
D08.811.913.696.620.682.700.931 TOR serin-threoninkinasy 196
D08.811.913.696.620.682.700.965 vakuolární třídící protein VPS15
D08.811.913.696.620.682.700.982 lysin-deficitní proteinkinasa WNK
D12.644 peptidy 1 395
D12.644.360.325.300.099.500 protoonkogenní proteiny c-bcr 19
D12.644.360.325.300.099.750 protoonkogenní proteiny c-vav 4
D12.776 proteiny 2 587
D12.776.476.325.300.099.500 protoonkogenní proteiny c-bcr 19
D12.776.476.325.300.099.750 protoonkogenní proteiny c-vav 4
D12.776.476.563 protein-serin-threoninkinasy 274
D12.776.476.563.062 aktivinové receptory 5
D12.776.476.563.085 proteinkinasy aktivované AMP 43
D12.776.476.563.097 ATM protein 92
D12.776.476.563.103 kinasy Aurora 4
D12.776.476.563.108 homolog Atg1 1
D12.776.476.563.140 kaseinkinasy 1
D12.776.476.563.143 checkpoint kinasa 1 20
D12.776.476.563.145 checkpoint kinasa 2 51
D12.776.476.563.250 proteinkinasa aktivovaná DNA 15
D12.776.476.563.288 kinasy Dyrk
D12.776.476.563.300 kinasa eIF-2 8
D12.776.476.563.397 kinázy zárodečného centra 2
D12.776.476.563.429 kinasy glykogensynthasy
D12.776.476.563.494 kinasa I-kappa B 9
D12.776.476.563.534 LRRK2 4
D12.776.476.563.542 Lim-kinasy 2
D12.776.476.563.554 MAP kinasy kinas (kinas) 48
D12.776.476.563.576 DM-kinasa 2
D12.776.476.563.579 kinasa indukující NF-kappaB 1
D12.776.476.563.581 kinasy NEK 4
D12.776.476.563.586 onkogenní protein v-akt 5
D12.776.476.563.596 p21 aktivované kinasy 9
D12.776.476.563.606 fytochrom A 2
D12.776.476.563.616 polo-like kinasy
D12.776.476.563.725 proteinkinasa C 139
D12.776.476.563.745 proteinkinasy PDK
D12.776.476.563.750 proteinkinasa D2
D12.776.476.563.755 protoonkogenní proteiny c-akt 123
D12.776.476.563.759 protoonkogenní proteiny c-bcr 19
D12.776.476.563.783 PDH-kinasa 1
D12.776.476.563.789 TGF-beta receptor I. typu 2
D12.776.476.563.795 TGF-beta receptor II. typu
D12.776.476.563.814 kinázy asociované s Rho 26
D12.776.476.563.897 serin-threoninkinasa 3
D12.776.476.563.931 TOR serin-threoninkinasy 196
D12.776.624 nádorové proteiny 418
D12.776.624.664 onkogenní proteiny 125
D12.776.624.664.700 protoonkogenní proteiny 266
D12.776.624.664.700.013 tyrozinkinasový receptor AXL
D12.776.624.664.700.025 protein BCL2L11 5
D12.776.624.664.700.037 tyrosinkinasa c-Mer 2
D12.776.624.664.700.049 chemokin CXCL1 7
D12.776.624.664.700.100 cyklin D1 87
D12.776.624.664.700.110 fibroblastový růstový faktor 4 2
D12.776.624.664.700.112 fibroblastový růstový faktor 6
D12.776.624.664.700.114 tyrosinkinasa 3 podobná fms 54
D12.776.624.664.700.117 Janus kinasa 2 80
D12.776.624.664.700.119 protein KRIT1
D12.776.624.664.700.120 KLF6 1
D12.776.624.664.700.123 lipokalin-2 21
D12.776.624.664.700.129 protein MDS1 and EVI1 complex locus 2
D12.776.624.664.700.130 homolog 2 proteinu MutS 17
D12.776.624.664.700.148 protoonkogenní protein MLL 39
D12.776.624.664.700.158 protoonkogen n-myc 9
D12.776.624.664.700.165 protein bcl-3
D12.776.624.664.700.166 protoonkogen Mas 4
D12.776.624.664.700.167 protoonkogenní proteiny c-abl 8
D12.776.624.664.700.168 protoonkogenní proteiny c-akt 123
D12.776.624.664.700.169 protoonkogenní proteiny c-bcl-2 153
D12.776.624.664.700.170 protoonkogenní proteiny c-bcl-6 3
D12.776.624.664.700.171 protoonkogenní proteiny c-bcr 19
D12.776.624.664.700.171.500 bcr-abl fúzní proteiny 240
D12.776.624.664.700.172 protoonkogenní proteiny c-cbl 6
D12.776.624.664.700.174 protoonkogenní proteiny c-crk 1
D12.776.624.664.700.175 protoonkogenní proteiny c-ets 19
D12.776.624.664.700.177 protoonkogenní proteiny c-fes
D12.776.624.664.700.179 protoonkogenní proteiny c-fos 63
D12.776.624.664.700.180 protoonkogenní proteiny c-fyn 4
D12.776.624.664.700.181 protoonkogenní proteiny c-hck 1
D12.776.624.664.700.182 protoonkogenní proteiny c-jun 18
D12.776.624.664.700.183 protoonkogenní proteiny c-kit 78
D12.776.624.664.700.184 protoonkogenní proteiny c-maf 1
D12.776.624.664.700.185 protoonkogenní proteiny c-mdm2 68
D12.776.624.664.700.186 protoonkogenní proteiny c-met 31
D12.776.624.664.700.187 protoonkogenní proteiny c-mos 2
D12.776.624.664.700.188 protoonkogenní proteiny c-myb 32
D12.776.624.664.700.189 protoonkogenní proteiny c-myc 69
D12.776.624.664.700.191 protoonkogenní proteiny c-pim-1 1
D12.776.624.664.700.192 protoonkogenní proteiny c-rel 2
D12.776.624.664.700.194 protoonkogenní proteiny c-ret 43
D12.776.624.664.700.195 protoonkogenní proteiny c-sis 3
D12.776.624.664.700.198 protoonkogenní proteiny c-vav 4
D12.776.624.664.700.199 protoonkogenní proteiny c-yes 1
D12.776.624.664.700.200 protoonkogenní proteiny p21(ras) 77
D12.776.624.664.700.202 protoonkogenní proteiny pp60(c-src) 7
D12.776.624.664.700.204 raf kinasy 70
D12.776.624.664.700.642 receptor erbB-2 606
D12.776.624.664.700.790 receptor erbB-3 9
D12.776.624.664.700.791 receptor ErbB-4
D12.776.624.664.700.815 receptor Notch4
D12.776.624.664.700.830 receptory thyreoidních hormonů 40
D12.776.624.664.700.913 protein EWS vázající RNA 17
D12.776.624.664.700.915 protein FUS vázající RNA 6
D12.776.624.664.700.936 protein RUNX1T1
D12.776.624.664.700.957 stathmin 4
D12.776.624.664.700.960 transkripční faktor TAL1
D12.776.624.664.700.962 protein Wnt 5a 5
D12.776.624.664.700.967 protein Wnt1 5
D12.776.624.664.700.978 protein Wnt2
D12.776.624.664.700.989 protein Gli1 8

BCR protein, human Chemical MeSH Prohlížeč

Bcr protein, mouse Chemical MeSH Prohlížeč