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Pracoviště: Cantacuzino Hospital Bucharest Romania K Chatzi...

1 záznamů v Medvik Filtry

Článek

Rituximab Retreatment in Rheumatoid Arthritis in a Real-life Cohort: Data from the CERERRA Collaboration

Chatzidionysiou, Katerina
Autor Chatzidionysiou, Katerina From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. aikaterini.chatzidionysiou@karolinska.se. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID). aikaterini.chatzidionysiou@karolinska.se
Lie, Elisabeth
Autor Lie, Elisabeth From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Lukina, Galina
Autor Lukina, Galina From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Hetland, Merete L
Autor Hetland, Merete L From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Hauge, Ellen-Margrethe
Autor Hauge, Ellen-Margrethe From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Pavelka, Karel
Autor Pavelka, Karel From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Gabay, Cem
Autor Gabay, Cem From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Scherer, Almut
Autor Scherer, Almut From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Nordström, Dan
Autor Nordström, Dan From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)
Canhao, Helena
Autor Canhao, Helena From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ARBITER, Institute of Rheumatology, Moscow, Russia DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark Institute of Rheumatology, Prague, Czech Republic Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva SCQM Foundation, Zurich, Switzerland National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia Rheumatology Department, Hospital Clinic of Barcelona, Barcelona Hospital Clinico Universidad De Santiago, Santiago, Spain Cantacuzino Hospital, Bucharest, Romania. K. Chatzidionysiou, MD, PhD, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID) E. Lie, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital G. Lukina, MD, PhD, ARBITER, Institute of Rheumatology M.L. Hetland, MD, PhD, Professor, DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen E.M. Hauge, MD, PhD, Department of Rheumatology, Aarhus University Hospital K. Pavelka, MD, PhD, Professor, Institute of Rheumatology C. Gabay, MD, PhD, Professor, SCQM Registry, University Hospital of Geneva A. Scherer, PhD, SCQM Foundation D. Nordström, MD, PhD, Professor, ROB-FIN, Helsinki University Central Hospital H. Canhao, MD, PhD, Professor, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M.J. Santos, MD, PhD, Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa M. Tomsic, MD, PhD, Professor, BioRx.si University Medical Centre Z. Rotar, MD, BioRx.si University Medical Centre M.V. Hernández, MD, PhD, Rheumatology Department, Hospital Clinic of Barcelona J. Gomez-Reino, MD, PhD, Professor, Hospital Clinico Universidad De Santiago I. Ancuta, MD, Cantacuzino Hospital T.K. Kvien, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital R. van Vollenhoven, MD, PhD, Professor, Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID)

Journal of rheumatology. 2017 ; 44 (2) : 162-169. [pub] 20170115

J Rheumatol
ISSN 0315-162X
Medvik
Zdroj

OBJECTIVE: Several aspects of rituximab (RTX) retreatment in rheumatoid arthritis (RA) need to be further elucidated. The aim of this study was to describe the effect of repeated courses of RTX on disease activity and to compare 2 retreatment strategies, fixed-interval versus on-flare retreatment, in a large international, observational, collaborative study. METHODS: In the first analysis, patients with RA who received at least 4 cycles with RTX were included. In the second analysis, patients who received at least 1 RTX retreatment and for whom information about the strategy for retreatment was available were identified. Two retreatment strategies (fixed-interval vs on-flare) were compared by fitting-adjusted, mixed-effects models of 28-joint Disease Activity Score (DAS28) over time for first and second retreatment. RESULTS: A total of 1530 patients met the eligibility criteria for the first analysis. Significant reductions of mean DAS28 between the starts of subsequent treatment cycles were observed (at start of first treatment cycle: 5.5; second: 4.3; third: 3.8; and fourth: 3.5), suggesting improved response after each additional cycle (p < 0.0001 for all pairwise comparisons). A total of 800 patients qualified for the second analysis: 616 were retreated on flare and 184 at fixed interval. For the first retreatment, the fixed-interval retreatment group yielded significantly better results than the on-flare group (estimated marginal mean DAS28 = 3.8, 95% CI 3.6-4.1 vs 4.6, 95% CI 4.5-4.7, p < 0.0001). Similar results were found for the second retreatment. CONCLUSION: Repeated treatment with RTX leads to further clinical improvement after the first course of RTX. A fixed-interval retreatment strategy seems to be more effective than on-flare retreatment.

MeSH
antirevmatika terapeutické užití MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
opakovaná terapie MeSH
registrace MeSH
revmatoidní artritida diagnóza farmakoterapie MeSH
rituximab terapeutické užití MeSH
senioři MeSH
stupeň závažnosti nemoci MeSH
výsledek terapie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

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