Autism spectrum disorders (ASD) are characterized by impairments in social interaction and communication along with stereotyped patterns of behaviors. Over the past several decades, the prevalence of ASD has increased dramatically. ASD are highly multifactorial, with many risk factors acting together. Our review suggests that most risk factors are connected to immunoexcitotoxicity. Fluoride exposure is common as a result of the artificial fluoridation of drinking water and a dramatic increase in the volume of man-made industrial fluoride compounds released into the environment. Human exposure to environmental aluminum is extensive and appears to be growing. The long-term fluoride and aluminum burden have several health effects with a striking resemblance to the ASD. Moreover, both fluoride and aluminum interfere with a number of glycolytic enzymes, resulting in a significant suppression of cellular energy production. The synergistic interactions of fluoride and aluminum increase the potential neurotoxic effect particularly in children. Aluminofluoride complexes have effects on cell signaling, neurodevelopment, and neuronal function. We suggest that the burden with these new ecotoxicological factors could contribute to an alarming increase in the prevalence of ASD.
- MeSH
- adjuvancia farmaceutická škodlivé účinky MeSH
- centrální nervový systém imunologie účinky léků MeSH
- fluoridy * farmakologie škodlivé účinky MeSH
- hliník farmakologie škodlivé účinky MeSH
- látky znečišťující životní prostředí MeSH
- lékové interakce MeSH
- lidé MeSH
- mikroglie účinky léků MeSH
- neurotoxiny farmakologie škodlivé účinky MeSH
- poruchy autistického spektra * etiologie chemicky indukované imunologie MeSH
- receptory spřažené s G-proteiny MeSH
- sloučeniny fluoru škodlivé účinky MeSH
- sloučeniny hliníku škodlivé účinky MeSH
- vakcíny škodlivé účinky MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
