Antimicrobial hand gels have become extremely popular in recent years due to the COVID-19 pandemic. Frequent use of hand sanitising gel can lead to dryness and irritation of the skin. This work focuses on the preparation of antimicrobial acrylic acid (Carbomer)-based gels enhanced by non-traditional compounds-mandelic acid and essential oils-as a substitute for irritating ethanol. Physicochemical properties (pH and viscosity), stability and sensory attributes of the prepared gels were investigated. Antimicrobial activity against representative Gram-positive and Gram-negative bacteria and yeasts was determined. The prepared gels with mandelic acid and essential oil (cinnamon, clove, lemon, and thyme) proved to have antimicrobial activity and even better organoleptic properties than commercial ethanol-based antimicrobial gel. Further, results confirmed that the addition of mandelic acid had a desirable effect on gel properties (antimicrobial, consistency, stability). It has been shown that the essential oil/mandelic acid combination can be a dermatologically beneficial hand sanitiser compared to commercial products. Thus, the produced gels can be used as a natural alternative to alcohol-based daily hand hygiene sanitisers.

• MeSH
• antibakteriální látky MeSH
• antiinfekční látky * MeSH
• COVID-19 * MeSH
• dezinfekční prostředky na mytí rukou * MeSH
• ethanol MeSH
• gely MeSH
• gramnegativní bakterie MeSH
• grampozitivní bakterie MeSH
• lidé MeSH
• mikrobiální testy citlivosti MeSH
• oleje prchavé * MeSH
• pandemie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Zein is renewable plant protein with valuable film-forming properties that can be used as a packaging material. It is known that the addition of natural cross-linkers can enhance a film's tensile properties. In this study, we aimed to prepare antimicrobial zein-based films enriched with monolaurin, eugenol, oregano, and thyme essential oil. Films were prepared using the solvent casting technique from ethanol solution. Their physicochemical properties were investigated using structural, morphological, and thermal techniques. Polar and dispersive components were analyzed using two models to evaluate the effects on the surface free energy values. The antimicrobial activity was proven using a disk diffusion method and the suppression of bacterial growth was confirmed via a growth kinetics study with the Gompertz function. The films' morphological characteristics led to systems with uniform distribution of essential oils or eugenol droplets combined with a flat-plated structure of monolaurin. A unique combination of polyphenolic eugenol and amphiphilic monoglyceride provided highly stretchable films with enhanced barrier properties and efficiency against Gram-positive and Gram-negative bacteria, yeasts, and molds. The prepared zein-based films with tunable surface properties represent an alternative to non-renewable resources with a potential application as active packaging materials.

• MeSH
• antibakteriální látky farmakologie   MeSH
• antifungální látky farmakologie   MeSH
• biomechanika účinky léků   MeSH
• diferenciální skenovací kalorimetrie MeSH
• Escherichia coli účinky léků   MeSH
• eugenol farmakologie   MeSH
• laurany farmakologie   MeSH
• mikroskopie atomárních sil MeSH
• monoglyceridy farmakologie   MeSH
• obaly potravin * MeSH
• oleje prchavé farmakologie   MeSH
• pára MeSH
• permeabilita MeSH
• povrchové vlastnosti MeSH
• smáčivost MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• Staphylococcus aureus účinky léků   MeSH
• zein farmakologie   MeSH
• Publikační typ
• časopisecké články MeSH

A new hyaluronan derivative modified with β-cyclodextrin units (CD-HA) was prepared via the click reaction between propargylated hyaluronan and monoazido-cyclodextrin (CD) to achieve a degree of substitution of 4%. The modified hyaluronan was characterized by 1H-nuclear magnetic resonance spectroscopy (NMR) and size exclusion chromatography. Subsequent 1H-NMR and isothermal calorimetric titration experiments revealed that the CD units on CD-HA can form virtual 1:1, 1:2, and 1:3 complexes with one-, two-, and three-site adamantane-based guests, respectively. These results imply that the CD-HA chains used the multitopic guests to form a supramolecular cross-linked network. The free CD-HA polymer was readily restored by the addition of a competing macrocycle, which entrapped the cross-linking guests. Thus, we demonstrated that the new CD-HA polymer is a promising component for the construction of chemical stimuli-responsive supramolecular architectures.

• MeSH
• beta-cyklodextriny chemická syntéza   chemie   MeSH
• kalorimetrie MeSH
• kyselina hyaluronová chemická syntéza   chemie   MeSH
• magnetická rezonanční spektroskopie MeSH
• molekulární struktura * MeSH
• polymery chemická syntéza   chemie   MeSH
• syntetická chemie okamžité shody MeSH
• Publikační typ
• časopisecké články MeSH