- Publikační typ
- abstrakt z konference MeSH
Zobrazení pomocí metod nukleární medicíny u neurodegenerativních onemocnění umožňuje hodnotit funkční charakteristiky různých oblastí CNS. V diagnostice extrapyramidových onemocnění mají nezastupitelné místo DaT scan a MIBG, které jsou zaměřeny na diferenciální diagnostiku parkinsonismu. U kognitivních poruch má výjimečnou pozici zobrazení beta amyloidu pomocí PET. FDG PET má význam především ve výzkumu.
Methods of nuclear medicine enable functional neuroimaging of various brain structures in neurodegenerative diseases. DaT scan and MIBG play a key role in differentials diagnosis of parkinsonian syndromes, in the field of movement disorders. Beta-amyloid PET imaging has a unique position in imaging of cognitive disorders. FDG PET is currently a method with predominantly research applications.
- MeSH
- Alzheimerova nemoc diagnostické zobrazování diagnóza MeSH
- amyloidní beta-protein MeSH
- demence s Lewyho tělísky diagnostické zobrazování diagnóza MeSH
- jednofotonová emisní výpočetní tomografie metody MeSH
- lidé MeSH
- neurodegenerativní nemoci * diagnostické zobrazování diagnóza MeSH
- Parkinsonova nemoc diagnostické zobrazování diagnóza MeSH
- pozitronová emisní tomografie metody MeSH
- radioisotopová scintigrafie * metody MeSH
- Check Tag
- lidé MeSH
Background: Dance is a complex activity combining physical exercise with cognitive, social, and artistic stimulation. Objectives: We aimed to assess the effects of dance intervention (DI) on intra and inter-network resting-state functional connectivity (rs-FC) and its association to cognitive changes in a group of non-demented elderly participants. Methods: Participants were randomly assigned into two groups: DI and life as usual (LAU). Six-month-long DI consisted of supervised 60 min lessons three times per week. Resting-state fMRI data were processed using independent component analysis to evaluate the intra and inter-network connectivity of large-scale brain networks. Interaction between group (DI, LAU) and visit (baseline, follow-up) was assessed using ANOVA, and DI-induced changes in rs-FC were correlated with cognitive outcomes. Results: Data were analyzed in 68 participants (DI; n = 36 and LAU; n = 32). A significant behavioral effect was found in the attention domain, with Z scores increasing in the DI group and decreasing in the LAU group (p = 0.017). The DI as compared to LAU led to a significant rs-FC increase of the default mode network (DMN) and specific inter-network pairings, including insulo-opercular and right frontoparietal/frontoparietal control networks (p = 0.019 and p = 0.023), visual and language/DMN networks (p = 0.012 and p = 0.015), and cerebellar and visual/language networks (p = 0.015 and p = 0.003). The crosstalk of the insulo-opercular and right frontoparietal networks were associated with attention/executive domain Z-scores (R = 0.401, p = 0.015, and R = 0.412, p = 0.012). Conclusion: The DI led to intervention-specific complex brain plasticity changes that were of cognitive relevance.
- Publikační typ
- časopisecké články MeSH
18F-fluciclovine is a PET radiopharmaceutical used for the detection of recurrent prostate cancer in adult men after primary curative treatment with suspicion of recurrence based on elevated prostate-specific antigen level. Several incidental uptakes of 18F-fluciclovine in other tumour types have been described in the literature so far - in breast cancer, hepatocellular carcinoma, and malignant melanoma. Our case report presents a patient with oncological duplicity (prostate gland carcinoma and newly diagnosed neuroendocrine tumour) and with accumulation of fluciclovine in pathologically proved neuroendocrine tumour, later imagined also by octreotide SPECT/CT. To our knowledge, this is the first case of fluciclovine accumulated in a neuroendocrine tumour described in the literature.
- Publikační typ
- kazuistiky MeSH
Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Although diagnosis may be challenging, there is increasing evidence that the use of biomarkers according to 2017 revised criteria for diagnosis and management of dementia with Lewy bodies can increase diagnostic accuracy. Apart from nuclear medicine techniques, various magnetic resonance imaging (MRI) techniques have been utilized in attempt to enhance diagnostic accuracy. This chapter reviews structural, functional and diffusion MRI studies in DLB cohorts being compared to healthy controls, AD or dementia in Parkinson's disease (PDD). We also included relatively new MRI methods that may have potential to identify early DLB subjects and aim at examining brain iron and neuromelanin.
