Predmetom tejto štúdie bolo sledovanie vplyvu zmeny koncentrácie tenzidu a teploty na liberáciu liečiva z hydrogélov a ich tokové vlastnosti. Použitým tenzidom bol benzetóniumchlorid (BZCl), v koncentrácii – 0,01; 0,1 a 0,5 % (m/m). Liečivo chlórhexidíniumdichlorid (CHX) bolo použité v 0,1 % (m/m) koncentrácii. Vo funkcii gélotvornej látky bol použitý chitosan (CHIT) v 2,5 % (m/m) koncentrácii. V práci sa hodnotila liberácia liečiva a tenzidu v teplotnom intervale 25–40 °C. Najviac liečiva sa uvoľnilo pri teplote 40 °C, rovnako to bolo aj v prípade tenzidu. Zmenou koncentrácie tenzidu v géloch sa získali štatisticky významné rozdiely (P < 0,05) v uvoľňovaní CHX a BZCl. Na základe štúdie tokových vlastností gélov sa zistilo, že zmena koncentrácie tenzidu neovplyvnila charakter plastickej sústavy. Na základe dosiahnutých výsledkov sa stanovil gél optimálneho zloženia: 2,5 % (m/m) CHIT + 0,1 % (m/m) CHX + 0,01 % (m/m) BZCl.
This study aimed to analyze the influence of surfactant concentration and temperature on drug liberation from hydrogels and their flow properties. The surfactant benzethonium chloride (BZCl) was used in concentrations of 0.01, 0.1 and 0.5 % (w/w), while the drug chlorhexidine dihydrochloride (CHX) was used in a concentration of 0.1 % (w/w). Chitosan (CHIT) in 2.5 % (w/w) concentration was used as a gel-creating substance. The drug and surfactant liberation were evaluated within the temperature range of 25–40 °C. The largest amounts of both of them were liberated at the temperature of 40 °C. Through the concentration changes it was possible to obtain statistically significant differences (P < 0.05) between the liberation of CHX and BZCl. An analysis of the flow properties revealed that the character of the plastic system was not influenced by the changing concentration of the surfactant. The experimental results led to the conclusion that the optimum composition of the gel was as follows: 2.5 % (w/w) CHIT + 0.1 % (w/w) CHX + 0.01 % (w/w) BZCl.
- MeSH
- Chemistry, Analytic MeSH
- Benzethonium * analogs & derivatives chemistry MeSH
- Biological Availability * MeSH
- Chemistry Techniques, Analytical methods instrumentation utilization MeSH
- Chitosan chemistry MeSH
- Chlorhexidine * analogs & derivatives chemistry MeSH
- Technology, Pharmaceutical MeSH
- Hydrogels * chemistry MeSH
- Indicators and Reagents MeSH
- Humans MeSH
- Micelles * MeSH
- Drug Carriers MeSH
- Drug Design MeSH
- Solubility MeSH
- Thermodynamics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Predmetom štúdia je formulácia lokálneho anestetika – trimekaín a antimykotika – terbinafín do hydrogélov s optimálnymi tokovými vlastnosťami. Ako gélotvorné látky boli vybrané deriváty celulózy: hydroxyetylcelulóza a hydroxypropylcelulóza. Hodnotili sa vzorky pripravené v rôznych kombináciach a koncentráciach tak, aby bola viskozita hydrogélu čo najvhodnejšia s ohľadom na použitie. Na základe hodnotenia reologických vlastností sa ako vhodný gélotvorný základ pre lokálne anestetikum trimekaín osvedčila kombinácia 1% trimekaín a 2% hydroxyetylcelulóza, pre antimykotikum terbinafín to bola kombinácia 1% terbinafín a 3% hydroxypropylcelulóza.
The study was concerned with the formulation of the local anaesthetic agent trimecaine and the antimycotic agent terbinafíne into hydrogels possessing the optimal flow properties. The gelling agents were the cellulose derivatives hydroxyethyl cellulose and hydroxypropyl cellulose. The evaluation included the samples in various combinations and concentrations prepared in such a way to produce the most suitable hydrogel viscosity with regard to the intended use. On the basis of the evaluation of the rheological properties, the suitable gelling base for the local anaesthetic trimecaine proved to be the combination of 1% trimecaine and 2% hydroxyethyl cellulose, and for the antimycotic terbinafíne, the combination of 1% terbinafíne and 3% hydroxypropyl cellulose.
