Liphophilic formulations of pharmaceuticals are very promising methods of drug solubility improvement. Four types of the formulations are available: Self-emulsifying drug delivery systems (SEDDS) consist of oils, surfactants and cosolvents where the pharmaceutical ingredient are dissolved. These systems form o/w emulsions which can be administered in tablets, soft or hard gelatin capsules. The effectivity of SEDDS depends on many parameters, such as excipients or emulsion droplet size.
- MeSH
- Adjuvants, Pharmaceutic * MeSH
- Biological Availability * MeSH
- Emulsions MeSH
- Technology, Pharmaceutical MeSH
- Drug Evaluation MeSH
- Dosage Forms * MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Surface-Active Agents * MeSH
- Solubility * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), diffe¬rential thermal analysis (DTA), differential scanning calori¬metry (DSC) and other sensitive and specific methods. The present review deals with application of these me¬thods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs.
- Keywords
- termické metody, farmaceutický vývoj, DSC, skelný přechod, polymorfismus, kompatibilita,
- MeSH
- Chemistry Techniques, Analytical MeSH
- Calorimetry, Differential Scanning methods MeSH
- Technology, Pharmaceutical MeSH
- Chemistry, Physical MeSH
- Pharmaceutical Preparations MeSH
- Drug Compounding MeSH
- Thermography methods MeSH
- Thermogravimetry methods MeSH
- Research MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Pharmaceutical excipients may occur in polymorphs and other solid forms and as active pharmaceutical ingredients. Excipients, polymorphs or the forms are not specified in the patient information leaflets on the dosage forms. Polymorphs of lactose, mannitol and sorbitol, various forms of cellulose and its derivatives, starch forms and poly(N-vinylpyrrolidone) are discussed in detail here. Identification of polymorphs and other solid forms can be carried out by X-ray powder diffraction as well as by IR, Raman and solid-state NMR spectroscopies.
