- MeSH
- dítě MeSH
- hra a hračky psychologie MeSH
- kognice MeSH
- komunikace MeSH
- lidé MeSH
- motorické dovednosti MeSH
- percepce MeSH
- poruchy autistického spektra * diagnóza psychologie MeSH
- poruchy sociálního chování diagnóza klasifikace MeSH
- psychologické techniky klasifikace MeSH
- psychologické testy MeSH
- sociální přizpůsobení MeSH
- vývoj dítěte MeSH
- vztahy mezi lékařem a pacientem MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
OBJECTIVE: Anorexia nervosa (AN) is a serious and potentially life-threatening psychiatric disorder. Pharmacotherapeutic possibilities still remain limited. We sought to determine if there was a positive effect on body weight and body mass index (BMI) in AN patients being treated for depression or anxiety with mirtazapine. METHODS: Using a case-control design, we found nine female patients with AN who had been treated with mirtazapine for depression or anxiety during hospitalization in our department. We also found nine female controls with AN, who had not received any pharmacotherapy. The two groups of patients were matched according to age and BMI. Case and control groups did not differ significantly in age (15.2 +/- 1.9 Vs. 14.7 +/- 1.7 years; P = 0.549), or in BMI (15.6 +/- 2.3 Vs. 15.6 +/- 2.1; P = 0.946) at baseline. Weight and BMI were evaluated at baseline and again after the patients had completed 1, 2, 3 and 4 weeks of treatment. RESULTS: The mean dose of mirtazapine was 21.7 +/- 1.8 mg at the end of week 4. Using ANOVA Repeated Measures, we found no significant differences between cases and controls with regard to weight (P = 0.981) or BMI (P = 0.576). However, there was a non-significant trend in patients which had been treated with mirtazapine which showed slightly more improvement, in the measured parameters, at the end of weeks 1, 2 and 3, compared to controls. CONCLUSION: Results are limited by small sample size. However, the use of mirtazapine could be useful in the treatment of AN in adolescence.
- MeSH
- antidepresiva tricyklická terapeutické užití MeSH
- financování organizované MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- mentální anorexie farmakoterapie psychologie MeSH
- mianserin analogy a deriváty terapeutické užití MeSH
- mladiství MeSH
- rozvrh dávkování léků MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
The aim of our study was to subcategorize Autistic Spectrum Disorders (ASD) using a multidisciplinary approach. Sixty four autistic patients (mean age 9.4+/-5.6 years) were entered into a cluster analysis. The clustering analysis was based on MRI data. The clusters obtained did not differ significantly in the overall severity of autistic symptomatology as measured by the total score on the Childhood Autism Rating Scale (CARS). The clusters could be characterized as showing significant differences: Cluster 1: showed the largest sizes of the genu and splenium of the corpus callosum (CC), the lowest pregnancy order and the lowest frequency of facial dysmorphic features. Cluster 2: showed the largest sizes of the amygdala and hippocampus (HPC), the least abnormal visual response on the CARS, the lowest frequency of epilepsy and the least frequent abnormal psychomotor development during the first year of life. Cluster 3: showed the largest sizes of the caput of the nucleus caudatus (NC), the smallest sizes of the HPC and facial dysmorphic features were always present. Cluster 4: showed the smallest sizes of the genu and splenium of the CC, as well as the amygdala, and caput of the NC, the most abnormal visual response on the CARS, the highest frequency of epilepsy, the highest pregnancy order, abnormal psychomotor development during the first year of life was always present and facial dysmorphic features were always present. This multidisciplinary approach seems to be a promising method for subtyping autism.
