Effect of indoor radon concentrations higher than 500 Bq m-3 in dwellings on excretion of 210Po was studied in 28 volunteers. The study was further augmented by following eight individuals from the group for 5 months at 1-month intervals. Association between 222Rn concentration in homes and 210Po excretion was found when the dataset containing values of the studied 27 subjects was combined with data on 40 Prague inhabitants from the previous study. Sources of uncertainties involved in the analysis are discussed.

• MeSH
• bydlení MeSH
• lidé MeSH
• polonium moč   MeSH
• radioaktivní látky znečišťující půdu analýza   MeSH
• radioaktivní látky znečišťující vzduch analýza   MeSH
• radon analýza   MeSH
• zdraví dobrovolníci pro lékařské studie MeSH
• znečištění vzduchu ve vnitřním prostředí analýza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

The most important dosimetry quantity that is determined at radiotherapy centers is the absorbed dose to water for external beams. Fixed tolerances for absorbed doses measured under reference conditions with an ionization chamber for high-energy photon and electron beams are usually 2 and 3%, respectively, regardless of uncertainties of the input variables and other conditions during evaluation. In reality, this agreement should be evaluated considering the uncertainties of the input variables because they affect the size of the random deviations of the measurements from their true values. The aim of this work was to develop a new approach to evaluate the agreement between measured and reported values based on statistical interference rather than to use fixed tolerance levels. The proposed method considers different scenarios that can occur during the evaluation of agreement. Because the method is described in general, it can be used in all similar situations when partial uncertainties can be established.

• MeSH
• celková dávka radioterapie MeSH
• kalibrace MeSH
• lidé MeSH
• nádory radioterapie   MeSH
• nejistota MeSH
• plánování radioterapie pomocí počítače metody   normy   MeSH
• radioterapie s modulovanou intenzitou metody   normy   MeSH
• statistické modely * MeSH
• vysokoenergetická radioterapie normy   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

The aim of the study is to make a comparison of daily 238U excretion in urine among 115 active uranium miners and its modeled values obtained from inhalation intake of long-lived alpha emitters as measured by personal dosemeters and assessed by biokinetic models for different absorption parameters settings for inhaled uranium. A total of 144 spot samples of urine were collected. The 238U content was measured using high-resolution inductively coupled plasma mass spectrometry method. To obtain estimates of the daily excreted values, the daily values were calculated according to the expected daily excretion of creatinine assessed individually for each miner. When determining the relation between the experimentally found data and the modeled data, a high emphasis was placed on uncertainty of the both compared quantities. All the tested absorption parameters settings produced in average 1.4-4.7-fold higher values than the experimentally found values in the urine.

• MeSH
• alfa částice MeSH
• hornictví * MeSH
• lidé MeSH
• monitorování radiace metody   MeSH
• pracovní expozice analýza   MeSH
• radiační expozice MeSH
• radioaktivní látky znečišťující vzduch analýza   MeSH
• spektrofotometrie atomová MeSH
• uran analýza   moč   MeSH
• záření gama MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

This paper assesses the coverage probability of commonly used confidence intervals for the standardized mortality ratio (SMR) when death certificates are missing. It also proposes alternative confidence interval approaches with coverage probabilities close to .95. In epidemiology, the SMR is an important measure of risk of disease mortality (or incidence) to compare a specific group to a reference population. The appropriate confidence interval for the SMR is crucial, especially when the SMR is close to 1.0 and the statistical significance of the risk needs to be determined. There are several ways to calculate confidence intervals, depending on a study characteristics (ie, studies with small number of deaths, studies with small counts, aggregate SMRs based on several countries or time periods, and studies with missing death certificates). This paper summarizes the most commonly used confidence intervals and newly applies several existing approaches not previously used for SMR confidence intervals. The coverage probability and length of the different confidence intervals are assessed using a simulation study and different scenarios. The performance of the confidence intervals for the lung cancer SMR and all other cancer SMR is also assessed using the dataset of French and Czech uranium miners. Finally, the most appropriate confidence intervals to use under different study scenarios are recommended.

• MeSH
• interval spolehlivosti * MeSH
• lidé MeSH
• mortalita * MeSH
• nádory plic mortalita   MeSH
• nemoci z povolání mortalita   MeSH
• pravděpodobnost MeSH
• rizikové faktory MeSH
• statistické modely MeSH
• úmrtní listy * MeSH
• uran MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Francie epidemiologie   MeSH

• Klíčová slova
• nukleární zařízení, studie INWORKS,
• MeSH
• dávka záření MeSH
• jaderná energie MeSH
• klinická studie jako téma MeSH
• leukemie * MeSH
• lidé MeSH
• počítačová simulace MeSH
• pracovní expozice MeSH
• radiační expozice * MeSH
• výrobní a průmyslová zařízení * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH

The main aim of this study was to determine and evaluate urinary excretion of uranium in the general public of the Czech Republic. This value should serve as a baseline for distinguishing possible increase in uranium content in population living near legacy sites of mining and processing uranium ores and also to help to distinguish the proportion of the uranium content in urine among uranium miners resulting from inhaled dust. The geometric mean of the uranium concentration in urine of 74 inhabitants of the Czech Republic was 0.091 mBq/L (7.4 ng/L) with the 95% confidence interval 0.071-0.12 mBq/L (5.7-9.6 ng/L) respectively. The geometric mean of the daily excretion was 0.15 mBq/d (12.4 ng/d) with the 95% confidence interval 0.12-0.20 mBq/d (9.5-16.1 ng/d) respectively. Despite the legacy of uranium mines and plants processing uranium ore in the Czech Republic, the levels of uranium in urine and therefore, also human body content of uranium, is similar to other countries, esp. Germany, Slovenia and USA. Significant difference in the daily urinary excretion of uranium was found between individuals using public supply and private water wells as a source of drinking water. Age dependence of daily urinary excretion of uranium was not found. Mean values and their range are comparable to other countries, esp. Germany, Slovenia and USA.

• MeSH
• dávka záření MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• monitorování radiace * MeSH
• radiační expozice * MeSH
• radioaktivní látky znečišťující vodu moč   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• uran moč   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH