Comparison between the intended and performed motor action can be expected to occur in the final epoch of a voluntary movement. In search for electrophysiological correlates of this mental process the purpose of the current study was to identify intracerebral sites activated in final epoch of self-paced voluntary movement. Intracerebral EEG was recorded from 235 brain regions of 42 epileptic patients who performed self-paced voluntary movement task. Evoked potentials starting at 0 to 243ms after the peak of averaged, rectified electromyogram were identified in 21 regions of 13 subjects. The mean amplitude value of these late movement potentials (LMP) was 56.4±27.5μV. LMPs were observed in remote regions of mesiotemporal structures, cingulate, frontal, temporal, parietal, and occipital cortices. Closely before the LMP onset, a significant increase of phase synchronization was observed in all EEG record pairs in 9 of 10 examined subjects; p<0.001, Mann-Whitney U test. In conclusion, mesiotemporal structures, cingulate, frontal, temporal, parietal, and occipital cortices seem to represent integral functionally linked parts of network activated in final epoch of self-paced voluntary movement. Activation of this large-scale neuronal network was suggested to reflect a comparison process between the intended and actually performed motor action. Our results contribute to better understanding of neural mechanisms underlying goal-directed behavior crucial for creation of agentive experience.

• MeSH
• Adult MeSH
• Electroencephalography Phase Synchronization physiology   MeSH
• Electrocorticography methods   MeSH
• Epilepsy surgery   MeSH
• Evoked Potentials physiology   MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Motor Activity physiology   MeSH
• Hand physiology   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• Keywords
• EBS,
• MeSH
• Adult MeSH
• Electroencephalography Phase Synchronization * MeSH
• Electroencephalography * MeSH
• Epilepsy diagnosis   MeSH
• Clinical Studies as Topic MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

Though consisting of early and late components, the evoked potential preceding a voluntary movement (Bereitschaftspotential - BP) is often considered as a unitary phenomenon. By analyzing intracerebrally recorded BP we attempted to demonstrate that the components are electrophysiological correlates of separate operations. The BPs recorded in 42 epilepsy surgery candidates (28 men, 14 women; aged from 18 to 49 years) during self-paced clenching movements of the hand opposite to the explored hemisphere were investigated in the study. Microdeep intracerebral 5 to 15-contact electrodes were used. The averaged curves were calculated from approximately 30 trials in each case. All the records were taken with a binaural reference. The total number of explored brain regions was 235; the event-related premovement potentials were observed in 121 of them. Three types of premovement responses were observed: (i) the BP with both components; (ii) the BP with the early component only; and (iii) the BP with the late component only. The generators of the early one-component BP were demonstrated in two frontal cortical areas (precentral and middle frontal gyri) and in the parietal area known to be involved in action planning and decision making (precuneus). Some structures generating the early one-component BP were activated during movement; the others were without motor responsiveness. The results suggest a separate elaboration of functional task items in some and their integration in other brain structures, and the existence of volitional mechanisms of different hierarchical character.

• MeSH
• Time Factors MeSH
• Adult MeSH
• Electroencephalography MeSH
• Electromyography MeSH
• Epilepsy pathology   physiopathology   MeSH
• Contingent Negative Variation physiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Brain Mapping MeSH
• Adolescent MeSH
• Young Adult MeSH
• Cerebral Cortex physiopathology   MeSH
• Movement physiology   MeSH
• Decision Making MeSH
• Hand Strength physiology   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• Keywords
• komponenta N400 lidského sluchu,
• MeSH
• Adult MeSH
• Electroencephalography methods   utilization   MeSH
• Electromyography methods   utilization   MeSH
• Electrooculography * methods   utilization   MeSH
• Evoked Potentials physiology   MeSH
• Human Experimentation MeSH
• Contingent Negative Variation physiology   MeSH
• Humans MeSH
• Evoked Potentials, Auditory * physiology   MeSH
• Evoked Potentials, Somatosensory physiology   MeSH
• Statistics as Topic MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH