A group of 10 cats, both sexes, were studied for the effect of peroral administration of the meclophenoxate (Cetrexin, Léciva, 1.5 mg kg-1) + chlorprothixen (Chlorprothixen, Spofa, 0.045 mg kg-1) + caffeine (Coffeinum natrium benzoicum, Spofa, 0.15 mg kg-1) combination upon the fixation of conditioned alimentary motor reflexes to a sound signal in the course of a 10-week experiment. The mentioned combination of drugs demonstrated a beneficial protective influence on the fixed alimentary motor reflexes against laboratory stress. The results were compared with the earlier fixation of the same reflexes in another group of 11 cats under piracetam (Nootropil, U.C.B. 20 mg kg-1, s.c.). In both groups of animals, the development of reflexes was performed in regular alterations of experiments under the effect of the drugs and control experiments. The drugs were administered 1 hour before the experiments. Both groups of animals showed significantly fewer intersignal and other incorrect motor reactions on the days they were given the drugs than the controls did. The number of fixed correct reactions and their latencies displayed only moderate insignificant differences between the pharmacological trials and the controls. The conclusions is that the actual development of conditioned alimentary motor reflexes was not found to be influenced by the action of the mentioned drugs modifying psychological functions and mental states.
- MeSH
- chlorprothixen farmakologie MeSH
- klasické podmiňování účinky léků fyziologie MeSH
- kočky MeSH
- kofein farmakologie MeSH
- látky ovlivňující centrální nervový systém farmakologie MeSH
- meklofenoxát farmakologie MeSH
- piracetam farmakologie MeSH
- trávicí systém - fyziologické jevy * MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Reproduction of fixed conditioned alimentary motor reflexes in long-time laboratory kept cats in the course of the year is remarkably influenced by the sexual cycle. Estrus, anestrus, gestation and deliveries act upon the reflex reproduction in a similar way like deliberate application of experimental stress of various intensity. The study of the antistress efficacy of drugs modifying psychological functions and mental states in the method of reproduction of fixed alimentary motor reflexes under stress must specify the actual effect of experimental stress. Experimental sensory stress represented by intermittent sound of 98 dB and intermittent light (0.6 joules) acting with simultaneous frequency of 6 Hz was found to generally impair reflex reproduction over the whole period of twelve months. Correct response latencies were significantly prolonged and incorrect motor reactions significantly increased. If reflex reproduction was impaired due to the sexual cycle, simultaneous sensory stress still aggravates the impairment. The definition of the actual efficacy of experimental stressing thus necessarily requires regular control experiments in the course of the year with reproduction influenced neither by stress nor drugs at least at forthightly intervals.
- MeSH
- centrální nervový systém účinky léků MeSH
- ethanol aplikace a dávkování MeSH
- lidé MeSH
- řeč MeSH
- učení účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
- MeSH
- chlorprothixen MeSH
- fyziologický stres MeSH
- kočky MeSH
- kofein MeSH
- psychotropní léky MeSH
- reflex MeSH
- Check Tag
- kočky MeSH
- MeSH
- chlorprothixen MeSH
- klasické podmiňování MeSH
- kočky MeSH
- kofein MeSH
- meklofenoxát MeSH
- psychický stres MeSH
- pyrithioxin MeSH
- Check Tag
- kočky MeSH
- MeSH
- estrus MeSH
- fyziologický stres MeSH
- kočky MeSH
- psychotropní léky MeSH
- reflex účinky léků MeSH
- Check Tag
- kočky MeSH
