Mycosis fungoides (MF) displays a broad spectrum of clinical, histological, and phenotypic variants with different prognostic impact. CD8⁺CD56⁺MF is very rare. So far, only 5 patients with CD8⁺CD56⁺ MF were reported to date. All of the previously described patients with this phenotypic variant were adults at the time of diagnosis and often manifested with widespread poikilodermatous skin lesions. Here we describe the clinicopathological features of a juvenile form of CD8⁺CD56⁺ non-poikilodermatous MF in a 10-year-old girl. In our patient, the disease displayed an indolent course and excellent prognosis with complete remission after treatment with UV light, topical steroids, and methotrexate. The differential diagnosis of CD8⁺ epidermotropic lymphocytic infiltrates in children is discussed, and the cases of CD8⁺CD56⁺ MF reported in the literature are reviewed.
- MeSH
- antigeny CD56 imunologie MeSH
- antigeny CD8 imunologie MeSH
- dítě MeSH
- imunofenotypizace MeSH
- lidé MeSH
- mycosis fungoides imunologie patologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
- MeSH
- acetylcholin agonisté farmakologie škodlivé účinky MeSH
- endoteliny agonisté farmakologie škodlivé účinky MeSH
- histamin farmakologie škodlivé účinky MeSH
- kůže * inervace MeSH
- lidé MeSH
- mastocyty fyziologie klasifikace MeSH
- nervový růstový faktor fyziologie MeSH
- neurotrofní faktory fyziologie MeSH
- opioidní peptidy fyziologie MeSH
- proteasy fyziologie MeSH
- pruritus * etiologie farmakoterapie patofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
