Autoerotic asphyxia is a form of deviant sexual behavior that seeks sexual gratification by means of manipulation with one's own body resulting in asphyxia, and may sometimes turn out to be fatal. Autoerotic fatalities involving autoerotic asphyxia are divided into two groups: "typical" autoerotic fatalities involve mechanical compression of the neck, chest or abdomen, whereas "atypical" autoeroticism involves sexual self-stimulation by other means. Cases where asphyxiophilic behavior is accompanied by volatile substance abuse are reported to be rather rare, but may involve a high risk of fatal results. This paper presents a case of accidental "atypical" autoeroticism involving victim's abuse of toluene, which, combined with asphyxiophilic airway occlusion, led to death. For the sake of comprehensiveness, both a verbal description and a schematic representation of the major metabolic pathways of acute and chronic abuse metabolic markers is provided.
Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β(3)-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, while in the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary β(3)-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)™ and ZWIX(-)™ column was observed. On the basis of this intermolecular recognition model between the selectors and the given enantiomers an indirect assignment of the resolved enantiomer via chromatography is proposed.
The study deals with the GC-MS determination of acrylamide in various matrices. The proposed method involves bromination of acrylamide to 2,3-dibromopropanamide, its conversion to 2-bromopropenamide and the GC-MS determination. The method was used for the determination of acrylamide in water, gaseous products of combustion and in food such as potato chips and cookies. The measured concentrations of acrylamide ranged from 46 to 1980 g kg–1 the highest levels being found in ground coffee and tobacco smoke.
- MeSH
- akrylamid * analýza škodlivé účinky MeSH
- bezpečnost potravin MeSH
- chromatografie plynová * MeSH
- halogenace * MeSH
- hmotnostní spektrometrie * MeSH
- Maillardova reakce MeSH
- pitná voda MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí * MeSH
- Publikační typ
- práce podpořená grantem MeSH
