Acute respiratory distress syndrome (ARDS) is a serious medical condition occurring in patients with polytrauma, pulmonary or non-pulmonary sepsis, pneumonia and many other circumstances. It causes inflammation of the lung parenchyma leading to impaired gas exchange with a systemic release of inflammatory mediators, causing consequential lung tissue injury, hypoxemia and frequently multiple organ failure. The aim of current study was to describe expression of inflammatory markers (myeloperoxidase, CD163 and vascular endothelial growth factor) by the cells in acute phase of ARDS. The lung samples of a 20-year-old man who had suffered a serious motorbike accident were obtained for histological examination. He died on the seventh day as a consequence of respiratory failure. Our results imply that expression of CD163 was restricted to activated alveolar macrophages and monocytes. Immunopositivityof MPO was observed in neutrophil granulocytes within lung alveoli and lung blood vessels. Myeloperoxidase positivity was observed in alveolar macrophages, too. Vascular endothelial growth factor was expressed in cytoplasm of neutrophil granulocytes, monocytes, small-sized alveolar macrophages and type II pneumocytes localized mostly inside lung alveoli. On the contrary, no positivity was observed in lung endothelial cells of blood vessels.
- MeSH
- alveolární makrofágy imunologie metabolismus MeSH
- antigeny diferenciační myelomonocytární biosyntéza MeSH
- CD antigeny biosyntéza MeSH
- dopravní nehody MeSH
- imunohistochemie MeSH
- lidé MeSH
- mimosilniční motorová vozidla MeSH
- mladý dospělý MeSH
- monocyty imunologie metabolismus MeSH
- neutrofily imunologie metabolismus MeSH
- peroxidasa biosyntéza MeSH
- pneumocyty imunologie metabolismus MeSH
- receptory buněčného povrchu biosyntéza MeSH
- syndrom dechové tísně imunologie metabolismus patologie MeSH
- vaskulární endoteliální růstový faktor A biosyntéza MeSH
- Check Tag
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
Zistiť výskyt a rozsah CT diagnostikovaného kraniocerebrálneho poranenia u etylizovaných pacientov s ľahkým kraniocerebrálnym poranením (GCS 13-15). Metóda: Retrospektívna štúdia vykonaná všetkým etylizovaným pacientom starším ako 15 rokov vyšetrených na pracovisku v období 12 mesiacov (10/06–09/07) s ľahkým kraniocerebrálnym poranením (GCS 13–15). Informácie o stave vedomia, presnom mechanizme úrazu, o pridružených poraneniach v oblasti tváre a hlavy, o požití alkoholu a záver CT vyšetrení boli získané zo zdravotnej dokumentácie. Výsledky: Za 12 mesiacov bolo vyšetrených 151 etylizovaných pacientov s ľahkým kraniocerebrálnym poranením. Tridsaťštyri (22,5 %) pacientov malo pozitívny CT (CCT+) nález s diagnotikovanou zlomeninou lebečnej klenby/bázy alebo bol prítomný nález akútnej traumatickej intrakraniálnej lézie. Stotri (68,2 %) pacientov nevykazovalo žiadne CT známky poranenia v oblasti hlavy, 14 (9,3 %) pacientov utrpelo zlomeninu nosových kostí alebo čeľuste. Piati pacienti boli operovaní (3,3 %), z toho traja (2 %) pre impresívnu zlomeninu lebečnej klenby a dvaja (1,3 %) pre subdurálny hematóm. Najčastejším CT nálezom bola zlomenina lebky (21x) a subarachnoidálne krvácanie (15x). Záver: Prevalencia CCT+ nálezu u etylizovaných pacientov s ľahkým kraniocerebrálnym poranením bola 22,5 %. Neurochirurgickú intervenciu vyžadovalo 3,3% pacientov.
To find out severity of brain injury in alcohol intoxicated patients after mild (GCS 13-15) brain injury. METHODS: A retrospective study of all patients older than 15 years in whom cranial CT (CCT) scan was performed between October 2006 and September 2007. Information of alcohol intoxication, injury mechanism, details of facial/head injuries, admission GCS, CCT findings and type of treatment were retrieved from patients' medical records. RESULTS: There were 151 alcohol intoxicated patients.Thirty four (22.5%) patients had positive CCT scans for brain injury or basal/vault fracture. One hundred and three (68.2%) patients had no signs of head/facial injury on CCT scans, 14 (9.3%) patients had fractures of nasal bones or maxillary/frontal sinuses only. Five (3.3%) patients were operated, 3 (2%) for depressed skull fracture and 2 (1.3%) for subdural hematoma. The most frequent findings on CCT scan were vault fracture in 21 patients (61.8%) and subarachnoid haemorrhage in 15 patients (44.1%). CONCLUSION: The prevalence of brain injury in alcohol intoxicated patients after mild brain injury was 22.5% with the need for neurosurgical intervention in 3.3%.
