BACKGROUND: Panthenol is an active substance used in dermatology to protect the health of the skin, to treat defects in the morphology of the stratum corneum. In cosmetology, hydrating, softening, and barrier function of panthenol are utilized. Detailed studies evaluating the efficacy of panthenol in cosmetic and pharmaceutical semisolid formulations and establishing its optimum concentration are needed. OBJECTIVES: To investigate whether an addition of 5-13 wt% panthenol in o/w and w/o emulsions increases hydration and supports the barrier properties of the skin. Rheological properties and sensory analysis of prepared formulations are supplemented. METHODS: Noninvasive instrumental methods in vivo were used. The hydration and barrier effect of semisolid formulations on the skin were observed for 48 hour; testing was conducted on 40 women. The effect was compared with formulations without any content of panthenol. The rheological and organoleptic properties of the formulations were evaluated. RESULTS: After applying either form of the formulations containing 7-11 wt% of panthenol hydration of the skin increased, transepidermal water loss decreased. pH of the skin shifted toward neutral after application of tested formulations. The rheological properties of the formulations were influenced by the type of vehicle, the amount of panthenol, and temperature. Sensory evaluation of both semisolid forms revealed statistically significant differences in o/w formulations with regard to spreadability. CONCLUSIONS: The presence of panthenol in an o/w and w/o semisolid formulations significantly enhances skin barrier repair and hydration of the stratum corneum. Better vehicle for the active substance as regards hydration proved o/w formulations.
- MeSH
- čití, cítění účinky léků MeSH
- dermatologické látky farmakologie MeSH
- dospělí MeSH
- emulze farmakologie MeSH
- epidermis účinky léků fyziologie MeSH
- fyziologie kůže účinky léků MeSH
- hydrofobní a hydrofilní interakce MeSH
- kosmetické přípravky farmakologie MeSH
- kyselina pantothenová analogy a deriváty farmakologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- perspiratio insensibilis účinky léků MeSH
- příprava léků MeSH
- reologie MeSH
- voda metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- infarkt myokardu MeSH
- lidé MeSH
- sekundární prevence MeSH
- vzdělávání pacientů jako téma MeSH
- Check Tag
- lidé MeSH
One of the complications of "diabetes mellitus" is termed diabetic foot syndrome, the first symptoms of which include changes in the skin's condition and properties. The skin becomes dehydrated, dry, and prone to excessive formation of the horny layer, its barrier function becoming weakened. This function can be restored by applying suitable cosmetic excipients containing active substances. The aim of this study was to evaluate and compare the effects of commercially available cosmetic products (CPs) designed for the care of diabetic foot, through a group of selected volunteers using noninvasive bioengineering methods. Statistical surveys (p < 0.05) evaluated these CPs as regards to their hydration effect and barrier properties. Special attention was devoted to CPs with the declared content of 10% urea, and that the influence of this preparation's ability to hydrate and maintain epidermal water in the epidermis was confirmed.
- MeSH
- aplikace kožní MeSH
- diabetická noha patologie MeSH
- dospělí MeSH
- epidermis účinky léků metabolismus patologie MeSH
- glycerol aplikace a dávkování chemie MeSH
- kosmetické přípravky aplikace a dávkování chemie MeSH
- kožní absorpce MeSH
- lidé středního věku MeSH
- lidé MeSH
- močovina aplikace a dávkování chemie MeSH
- permeabilita MeSH
- pomocné látky aplikace a dávkování chemie MeSH
- voda metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
