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Publikace se zaměřuje na duševní pohodu transgender lidí a na poskytování zdravotní péče a psychoterapie těmto lidem. Určeno odborné veřejnosti.
- MeSH
- duševní zdraví MeSH
- genderová identita MeSH
- holistické zdraví MeSH
- poskytování zdravotní péče MeSH
- psychoterapeutické procesy MeSH
- transgender osoby MeSH
- transsexualismus MeSH
- zdraví menšin MeSH
- zdravotnické služby pro transgender osoby MeSH
- Publikační typ
- monografie MeSH
- práce podpořená grantem MeSH
- Konspekt
- Psychologie
- NLK Obory
- psychologie, klinická psychologie
- psychoterapie
- sociální lékařství
Mortality in psychiatric patients with severe mental illnesses reaches a 2-3 times higher mortality rate compared to the general population, primarily due to somatic comorbidities. A high prevalence of cardiovascular morbidity can be attributed to the adverse metabolic effects of atypical antipsychotics (atypical APs), but also to metabolic dysregulation present in drug-naïve patients. The metabolic aspects of neurodevelopmental schizophrenia-like models are understudied. This study evaluated the metabolic phenotype of a methylazoxymethanol (MAM) schizophrenia-like model together with the metabolic effects of three APs [olanzapine (OLA), risperidone (RIS) and haloperidol (HAL)] administered via long-acting formulations for 8 weeks in female rats. Body weight, feed efficiency, serum lipid profile, gastrointestinal and adipose tissue-derived hormones (leptin, ghrelin, glucagon and glucagon-like peptide 1) were determined. The lipid profile was assessed in APs-naïve MAM and control cohorts of both sexes. Body weight was not altered by the MAM model, though cumulative food intake and feed efficiency was lowered in the MAM compared to CTR animals. The effect of the APs was also present; body weight gain was increased by OLA and RIS, while OLA induced lower weight gain in the MAM rats. Further, the MAM model showed lower abdominal adiposity, while OLA increased it. Serum lipid profile revealed MAM model-induced alterations in both sexes; total, HDL and LDL cholesterol levels were increased. The MAM model did not exert significant alterations in hormonal parameters except for elevation in leptin level. The results support intrinsic metabolic dysregulation in the MAM model in both sexes, but the MAM model did not manifest higher sensitivity to metabolic effects induced by antipsychotic treatment.
- MeSH
- antipsychotika farmakologie terapeutické užití MeSH
- haloperidol farmakologie terapeutické užití MeSH
- metabolismus lipidů účinky léků MeSH
- metabolom účinky léků MeSH
- methylazoxymethanolacetát analogy a deriváty MeSH
- modely nemocí na zvířatech * MeSH
- olanzapin farmakologie terapeutické užití MeSH
- potkani Sprague-Dawley MeSH
- risperidon farmakologie terapeutické užití MeSH
- schizofrenie chemicky indukované farmakoterapie metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
OBJECTIVE: The finer scale patterns of arthropod vertical stratification in forests are rarely studied and poorly understood. Further, there are no studies investigating whether and how altitude affects arthropod vertical stratification in temperate forests. We therefore investigated the fine-scale vertical stratification of diversity and guild structure of saproxylic beetles in temperate lowland and montane forests and compared the resulting patterns between the two habitats. METHODS: The beetles were sampled with flight intercept traps arranged into vertical transects (sampling heights 0.4, 1.2, 7, 14, and 21 m). A triplet of such transects was installed in each of the five sites in the lowland and in the mountains; 75 traps were used in each forest type. RESULTS: 381 species were collected in the lowlands and 236 species in the mountains. Only 105 species (21%) were found at both habitats; in the montane forest as well as in the lowlands, the species richness peaked at 1.2 m, and the change in assemblage composition was most rapid near the ground. The assemblages clearly differed between the understorey (0.4 m, 1.2 m) and the canopy (7 m, 14 m, 21 m) and between the two sampling heights within the understorey, but less within the canopy. The stratification was better pronounced in the lowland, where canopy assemblages were richer than those near the forest floor (0.4 m). In the mountains the samples from 14 and 21 m were more species poor than those from the lower heights. The guild structure was similar in both habitats. CONCLUSIONS: The main patterns of vertical stratification and guild composition were strikingly similar between the montane and the lowland forest despite the low overlap of their faunas. The assemblages of saproxylic beetles were most stratified near ground. The comparisons of species richness between canopy and understorey may thus give contrasting results depending on the exact sampling height in the understorey.
- MeSH
- brouci klasifikace fyziologie MeSH
- druhová specificita MeSH
- ekosystém MeSH
- lesy * MeSH
- stravovací zvyklosti MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- odborná způsobilost MeSH
- poradenství MeSH
- Geografické názvy
- Česká republika MeSH
