The prosperity of brain parenchyma during aging depends on the preservation of cerebral blood flow (CBF) parameters. We have analysed ultrasonographic measurements of peak systolic (PSV) and end diastolic velocities (EDV) along with pulsatility (PI) and resistance indexes (RI) in common (CCA), internal (ICA) and external carotid artery (ECA) (N=199) and in vertebral arteries (VA) (N=200) in patients without any signs of stenosis. In two other cohorts patients with internal carotid artery stenosis (N=231) and patients prior to and after therapeutic recanalization (N=81) were evaluated in the same parameters. Results: in the range of 21-92 years PSV in CCA decreases by 7 mm/s/year, while in ICA only by 2.31 mm/s/year. The decrease of EDV in carotid arteries occurs between 1.72 and 2.28 mm/s/year. PSV in VA drops down by 0.91 mm/s/year, EDV by 0.86 mm/s/year. PI and RI increase with age in all vessels, but not significantly. Stenotic ICAs are associated with increased PSV in the range of 0.7-2.9 m/s, but also with an increasing PSV variability along the growing stenosis in individual patients. In all degrees of stenoses some patients preserve normal velocities. In average the increment for each 10% of the stenosis below 50% makes 8 cm/s, while above 50% it makes already 50 cm/s. In persons with bilateral stenoses the increment with growing stenosis is steeper. The restoration of normal ICA lumen by means of carotid endarterectomy or by angioplasty with stenting results in an average drop by 1.23 m/s in PSV and by 0.4 m/s in EDV. We have investigated the ophthalmic artery and other substitution supplies and deduce, that the remarkable differences in blood flow velocity reactions to a compromised carotid lumen depend on the formation of collaterals in mutual interplay with peripheral resistance.
- MeSH
- angioplastika statistika a číselné údaje MeSH
- arteria carotis communis chirurgie patofyziologie ultrasonografie MeSH
- arteria carotis externa chirurgie patofyziologie ultrasonografie MeSH
- arteria carotis interna chirurgie patofyziologie ultrasonografie MeSH
- arteria vertebralis chirurgie patofyziologie ultrasonografie MeSH
- dospělí MeSH
- financování organizované MeSH
- karotická endarterektomie statistika a číselné údaje MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozek krevní zásobení patofyziologie MeSH
- mozkový krevní oběh fyziologie MeSH
- obnova funkce fyziologie MeSH
- referenční hodnoty MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stárnutí fyziologie patologie MeSH
- stenóza arteria carotis chirurgie patofyziologie ultrasonografie MeSH
- stenty statistika a číselné údaje MeSH
- vertebrobazilární insuficience chirurgie patofyziologie ultrasonografie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
