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10 záznamů v Medvik Filtry

Článek

Phenolic compounds from Allium schoenoprasum, Tragopogon pratensis and Rumex acetosa and their antiproliferative effects

Molecules. 2011 ; 16 (11) : 9207-17. [pub] 20111103

ISSN 1420-3049
Medvik
Zdroj

Experimental studies have shown that phenolic compounds have antiproliferative and tumour arresting effects. The aim of this original study was to investigate the content of phenolic compounds (PhC) in flowers of Allium schoenoprasum (chive), Tragopogon pratensis (meadow salsify) and Rumex acetosa (common sorrel) and their effect on proliferation of HaCaT cells. Antiproliferative effects were evaluated in vitro using the following concentrations of phenolic compounds in cultivation medium: 100, 75, 50 and 25 µg/mL. Phenolic composition was also determined by HPLC. The results indicate that even low concentrations of these flowers' phenolic compounds inhibited cell proliferation significantly and the possible use of the studied herb's flowers as sources of active phenolic compounds for human nutrition.

MeSH
antitumorózní látky chemie farmakologie MeSH
fenoly chemie farmakologie MeSH
květy chemie MeSH
léky antitumorózní - screeningové testy MeSH
lidé MeSH
nádorové buněčné linie účinky léků MeSH
pažitka anatomie a histologie chemie MeSH
rostlinné extrakty chemie farmakologie MeSH
Rumex anatomie a histologie chemie MeSH
Tragopogon anatomie a histologie chemie MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

The effect of hydrolysis degree on the properties of antibacterial polymeric films based on poly(vinyl alcohol) and zinc sulphate for biomedical applications

Journal of biomaterials science. Polymer ed.. 2010 ; 21 (11) : 1421-40. [pub] 20100608

J Biomater Sci Polym Ed
ISSN 1568-5624
Medvik
Zdroj

Fully and partially hydrolyzed poly(vinyl alcohol) (PVA) was modified with zinc sulphate in the concentration range from 0 to 9 wt% of recalculated zinc content using the solvent cast technique. The resulting polymeric films were characterized by optical microscopy, stress-strain analysis, differential scanning calorimetry and Fourier transform infrared spectroscopy (FT-IR-ATR). In addition, agar diffusion test and dilution and spread plate technique were used for determination of antibacterial properties of the films against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacterial strains. A mathematical model was applied on the measured data and parameters characterizing the antibacterial efficiency of the material were calculated and discussed. The results revealed that the PVA hydrolysis degree can play an important role in all studied properties, including antibacterial activity of the all PVA-based materials.

Článek

Cell proliferation of HaCaT keratinocytes on collagen films modified by argon plasma treatment

Molecules. 2010 ; 15 (4) : 2845-56. [pub] 20100420

ISSN 1420-3049
Medvik
Zdroj

Argon plasma treatment was used to modify the surface of atelocollagen films using a plasmochemical reactor. To evaluate the effects of the treatment, the untreated and treated samples were characterized by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), Scanning Electron Microscopy (SEM) imaging, and X-ray Photoelectron Spectroscopy (XPS) techniques. Cell growth was carried out by culturing human immortalized keratinocyte (HaCaT) cells and proliferation was measured via MTT assay. It was observed that argon plasma treatment significantly enhanced the extent of cell proliferation, which was ascribed to the favourable role of plasma treatment in inducing surface oxygen-containing entities together with increasing surface roughness. This can be considered as a potentially promising approach for tissue regeneration purposes.