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99 záznamů v Medvik Filtry

Článek

The effect of prenatal methamphetamine exposure on recognition memory in adult rats

Fialová, Markéta
Autor Autorita Department of Brain Pathophysiology and Biochemistry, Prague Psychiatric Center, Prague, Czech Republic
Šírová, Jana
Autor Autorita ORCID Department of Brain Pathophysiology and Biochemistry, Prague Psychiatric Center, Prague, Czech Republic
Valešová, Věra, 1977-
Autor Autorita Department of Brain Pathophysiology and Biochemistry, Prague Psychiatric Center, Prague, Czech Republic
Šlamberová, Romana
Autor Autorita ORCID Department of Normal, Pathological, and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

Prague Medical Report. 2015 ; 116 (1) : 31-39.

Prague Med. Rep.
ISSN 1214-6994
Medvik
Zdroj

The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspring was administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an experiment. For testing recognition memory two tasks were chosen: Novel Object Recognition Test (NORT) and Object Location Test (OLT). Our results demonstrate that prenatally MA-exposed animals were worse in NORT independently on an acute administration of MA in adulthood. Prenatally MA-exposed rats did not deteriorate in OLT, but after acute administration of MA in adulthood, there was significant worsening compared to appropriate control. Prenatally saline-exposed offspring did not deteriorate in any test even after acute administration of MA. Our data suggest that prenatal MA exposure in rats cause impairment in recognition memory in adult offspring, but not in spatial memory. In addition, acute administration of MA to controls did not deteriorate either recognition or spatial memory.

Článek

Prenatal methamphetamine exposure induces long-lasting alterations in memory and development of NMDA receptors in the hippocampus

Physiological research. 2014 ; 63 (Suppl. 4) : S547-S558.

Physiol. Res. (Print)
ISSN 1802-9973
Medvik
Zdroj

Proceedings of the ... Physiological days. 2014 ; () : S547-S558.

Medvik
Zdroj

Since close relationship was shown between drug addiction and memory formation, the aim of the present study was to investigate the effects of interaction between prenatal methamphetamine (MA) exposure and MA treatment in adulthood on spatial and non-spatial memory and on the structure of the N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Adult male rats prenatally exposed to MA (5 mg/kg) or saline were tested in adulthood. Non-spatial memory was examined in the Object Recognition Test (ORT) and spatial memory in the Object Location Test (OLT) and in the Memory Retention Test (MRT) conducted in the Morris Water Maze (MWM), respectively. Based on the type of the memory test animals were injected either acutely (ORT, OLT) or long-term (MWM) with MA (1 mg/kg). After each testing, animals were sacrificed and brains were removed. The hippocampus was then examined in Western Blot analysis for occurrence of different NMDA receptors' subtypes. Our results demonstrated that prenatal MA exposure affects the development of the NMDA receptors in the hippocampus that might correspond with improvement of spatial memory tested in adulthood in the MWM. On the other hand, the effect of prenatal MA exposure on non-spatial memory examined in the ORT was the opposite. In addition, we showed that the effect of MA administration in adulthood on NMDA receptors is influenced by prenatal MA exposure, which seems to correlate with the spatial memory examined in the OLT.

Abstrakt

Existují pohlavní rozdíly ve farmakokinetice metamfetaminu u dospělých samců a samic laboratorního potkana?

Psychiatrie (Praha, Print). 2013 ; 17 (Suppl. 1) : 49. (55. česko-slovenská psychofarmakologická konference: Jeseník, 4.-8.1.2013)

Psychiatrie (Praha Print)
ISSN 1211-7579
Medvik
Zdroj

Česko-slovenská psychofarmakologická konference. 2013 ; 17 (Suppl. 1) : 49.

Medvik
Zdroj

Publikační typ
abstrakt z konference MeSH

Článek

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Psychopharmacology. 2013 ; 225 (1) : 75-93.

ISSN 1432-2072
Medvik
Zdroj

RATIONALE AND OBJECTIVES: Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. MATERIALS AND METHODS: Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. RESULTS: 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence was observed. Amphetamine mainly induced an increase in EEG power and coherence in theta and alpha bands. Increases in the theta and alpha power and coherence in 2C-B and amphetamine were temporally linked to an increase in locomotor activity and DA levels in NAc. CONCLUSIONS: 2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed.

Výzkumná zpráva

Sexuální rozdíly v účincích 3,4-methylendioxymetamfetaminu ( MDMA ) na kognitivní funkce, neurogenezi a farmakokinetické parametry

Valešová, Věra, 1977-
Autor Autorita
Psychiatrické centrum Praha
Autor Autorita

Praha : Iga MZ ČR, 2012

Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR

65 l. : il., tab. ; 30 cm

This project studies the sex differences in the effect of MDMA (ecstasy) on pharmacokinetic parameters, cognitive function and neurogenesis in young adult rats. the results will contribute to exhibiting sex differences in the pharmacokinetics of MDMA andthe effect of sex hormones on the pharmacodynamics of MDMA with potential effect upon memory, learning and neurogenesis in the hippocampus. The results from this study may improve the mental health and well-being of young people using MDMA and will clarify the cause of long-term changes in MDMA users. In addition, this project will contribute to finding sex differences in the toxic effect of the drug.

Pohlavní rozdíly v účincích MDMA (extáze) na farmakokinetické parametry, poznávací funkce a neurogenezi u dospělých potkanů. Výsledky objasní sexuální rozdíly ve farmakokinetice MDMA a vliv pohlavních hormonů na farmakodynamiku MDMA s potenciálními účinky na paměť, učení a vznik nových neuronů v hipokampu dospělých potkanů. Řešení přispěje k ochraně duše vního zdraví uživatelů MDMA a objasní příčiny dlouhodobých změn u uživatelů této drogy. Navíc přispěje ke zjištění rozdílu účinku a toxicitě dané látkymezii pohlavím.