AIM: Understanding cardiac electronic device infective endocarditis epidemiology is essential for the management of this serious complication. Only monocentric and limited data have been published regarding patients in the Czech republic so far. The aim of this study was to describe the current profile, microbiology and clinical characteristics of this population. PATIENTS AND METHODS: National data from the prospective ESC-EORP EURO-ENDO registry were collected. 57 consecutive patients with a diagnosis of cardiac device-related infective endocarditis (CDRIE) from 11 Czech centres were included. RESULTS: Staphylococcus spp. was responsible for 43.9% of isolates, whereas Culture negative endocarditis was documented in 26.3% episodes. The most frequent complications under therapy were acute renal failure (17.5%), septic shock and heart failure (both 10.5%). Extraction of device was performed in 75.4% of all patients, and the 1-year mortality was 22.5%. CONCLUSIONS: The high proportion of culture-negative endocarditis is alarming and warrants further investigation. Cardiac device related infective endocarditis is a serious complication with a high 1-year mortality in a highly polymorbid spectrum of patients.

• MeSH
• Endocarditis, Bacterial * epidemiology   etiology   MeSH
• Defibrillators, Implantable * adverse effects   MeSH
• Endocarditis * complications   etiology   MeSH
• Humans MeSH
• Prospective Studies MeSH
• Registries MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

INTRODUCTION: Data describing contemporary profile of infective endocarditis (IE) in the Czech Republic are lacking. The aim of this study was to describe the current profile and outcomes of IE patients. METHODS: Prospectively collected data on consecutive patients admitted for IE diagnosis between April 2016 and March 2018 to 11 main tertiary care cardiac centers in the Czech Republic were used for this analysis. RESULTS: Among 208 patients, 88 patients (42.3 %) had native valve IE (NVIE), 56 patients (26.9 %) had prosthetic valve IE (PVIE), and 57 patients (27.4 %) had intracardiac device-related IE (CDRIE). The mean age was 61.66±15.54 years. Staphylococcus aureus was the most common etiological agent of IE (27.4 %), whereas Culture negative IE was present in 26.4 % patients. Surgery was performed during hospitalization in 112 (53.8 %) patients. In-hospital death occurred in 21.2 % patients, while 1-year mortality was 40.3 %. In patients, who had an indication for surgery, but the procedure was not performed, mortality was significantly higher (p=0.002). CONCLUSION: High proportion of culture negative IE and IE related to artificial intra-cardiac materials calls for action. Furthermore, we show that cardiac surgery should be more often contemplated, especially in the presence of risk factors as septic shock and congestive heart failure (Tab. 6, Fig. 1, Ref. 32).

• MeSH
• Endocarditis, Bacterial * diagnosis   epidemiology   therapy   MeSH
• Middle Aged MeSH
• Humans MeSH
• Hospital Mortality MeSH
• Prospective Studies MeSH
• Registries MeSH
• Risk Factors MeSH
• Aged MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

Důsledkem těžké intoxikace oxidem uhelnatým (CO) je hypoxemické a histotoxické poškození. Účinkem CO na myokard vznikají tranzitorní globální i segmentární poruchy kinetiky levé či obou komor srdečních a je popisován proarytmogenní efekt. Stresová kardiomyopatie je charakteristická dočasnými lokalizovanými poruchami kinetiky, nejčastěji v oblasti apikálních segmentů levé komory srdeční, méně časté jsou izolované poruchy kinetiky středních či bazálních segmentů či postižení obou komor. Předkládáme případ 34letého muže, který byl přijat na Kliniku anesteziologie, resuscitace a intenzivní medicíny (KARIM) LF a FN Plzeň po intoxikaci oxidem uhelnatým v suicidálním pokusu. Echokardiograficky byla v úvodu zjištěna těžká systolická dysfunkce obou srdečních komor. Levá komora srdeční vykazovala akinezu středních segmentů a částečně zachovanou kinetiku apikálních a bazálních segmentů. Přes rozvoj těžkého kardiogenního šoku byl stav terapeuticky zvládnut umělou plicní ventilací, normobarickou oxygenoterapií a dočasnou léčbou katecholaminy. Do 2 týdnů se kompletně reparovala systolická funkce obou komor a nedošlo k trvalé hypoxické lézi centrální nervové soustavy. Stav připouští možnost souběhu toxické kardiomyopatie při otravě oxidem uhelnatým s tako-tsubo kardiomyopatií jako somatického důsledku dlouhodobé zátěže, která mohla vést až k suicidálnímu pokusu. Literární data naznačují, že stresová i toxická kardiomyopatie po otravě CO se často vyskytují současně, neboť jejich patofyziologické mechanizmy se do určité míry překrývají. Obě klinické jednotky mají po překlenutí akutní fáze dobrou prognózu.

Severe carbon monoxide intoxication may cause tissue injury by hypoxemia and histotoxicity. The affection of the heart muscle often leads to transient global or regional systolic dysfunction of left ventricle or both ventricles and increased occurences of malignant arrhytmias. On the contrary, stress-induced cardiomyopathy is described as temporary segmental loss of contractility, mostly in apical segments of the left ventricle with mid- and basal sparing and less common hypokinesias in mid- or basal parts, or affection of both ventricles. This case report is dedicated to 34-years old male, who was admitted to the department of emergency medicine after suicide attempt by carbon monoxide poisoning. Echocardiography at admission showed akinesias of midsegments of left ventricle and severe hypokinesias of apical and basal segments. Despite severe cardiogenic shock, adequate therapeutic management including mechanical ventilation, normobaric oxygenotherapy and catecholamine treatment led to complete somatic recovery after 2 weeks, and without any permanent hypoxemic brain injury. Our case might be coincidence of toxic cardiomyopathy, caused by carbon monoxide poisoning, and takotsubo cardiomyopathy as result of long term exposition to combined stress factors that may lead even to suicide attempt. Both types of cardiomyopathies often occure simultaneously due to similar pathophysiologic mechanisms. Both tako-tsubo and toxic cardiomypathy have good prognosis after overcoming the acute phase.

• MeSH
• Adult MeSH
• Electrocardiography methods   MeSH
• Shock, Cardiogenic diagnosis   etiology   therapy   MeSH
• Cardiomyopathies * diagnosis   etiology   therapy   MeSH
• Clinical Laboratory Techniques MeSH
• Humans MeSH
• Carbon Monoxide Poisoning * complications   physiopathology   therapy   MeSH
• Suicide, Attempted MeSH
• Takotsubo Cardiomyopathy * diagnosis   etiology   therapy   MeSH
• Emergency Medical Services MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH