BACKGROUND: Four recent transmissions of variant Creutzfeldt-Jakob disease infection by transfusion highlight the need for detailed understanding of blood-related prion pathogenesis. Nonhuman primates are the most relevant models of human prion diseases.
- MeSH
- druhová specificita MeSH
- erytrocyty metabolismus MeSH
- financování organizované MeSH
- granulocyty metabolismus MeSH
- Lemur krev MeSH
- leukocyty metabolismus MeSH
- lidé MeSH
- lymfocyty metabolismus MeSH
- Macaca krev MeSH
- monocyty metabolismus MeSH
- monoklonální protilátky imunologie MeSH
- Pan troglodytes krev MeSH
- primáti krev MeSH
- priony analýza krev metabolismus MeSH
- průtoková cytometrie MeSH
- Saimiri krev MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
The ubiquitous feature of the nervous system of wide spread occurrence of complex dynamics behaviour is treated. The cardinal question concerning the nature of generators of such complex behaviour, namely if it is ad hoc random or deterministic but strongly nonlinear, is analyzed. It is proved analytically that the discrete dynamics of single neurons with the sigmoidal transfer function is potentially chaotic. As the by-product the functional gain-threshold mechanism in neurons is derived. This allows for the new interpretations of famous experiments by Miyashita on squirell monkeys. Then it is shown that the continuous dynamics of the neural circuits of two-three neurons are endowed with the potentiality of chaotic firing, too. Finally, it will be argued that the classical dogma of stochastic or the ad hoc random neural coding can be taken as the limiting case of presenting new approach of deterministic or chaotic paradigm.
Eight coagulase-negative, oxidase-negative and novobiocin-susceptible staphylococcal strains were isolated from the gastrointestinal tracts of South American squirrel monkeys (Saimiri sciureus L.). These strains were differentiated from known staphylococcal species on the basis of 16S rRNA gene and hsp60 gene sequencing, and from the most closely related species by using DNA-DNA hybridization, ribotyping, whole-cell protein profiles and biotyping. Phylogenetic analysis based on 16S rRNA gene sequences confirmed that these strains are members of the Staphylococcus aureus species group (99% similarity) but are biochemically similar to Staphylococcus piscifermentans, from which they can be phenotypically distinguished by resistance to polymyxin B, acid production from D-mannitol, the inability to hydrolyse aesculin and DNA and the absence of alpha-glucosidase. On the basis of these analyses, a novel species of the genus Staphylococcus is described, for which the name Staphylococcus simiae sp. nov. is proposed, with CCM 7213(T) (=LMG 22723(T)) as the type strain.
- MeSH
- bakteriální proteiny analýza MeSH
- chaperon hsp60 genetika MeSH
- DNA bakterií analýza MeSH
- financování organizované MeSH
- fylogeneze MeSH
- gastrointestinální trakt mikrobiologie MeSH
- geny rRNA MeSH
- hybridizace nukleových kyselin MeSH
- molekulární sekvence - údaje MeSH
- ribotypizace MeSH
- RNA ribozomální 16S genetika MeSH
- Saimiri mikrobiologie MeSH
- sekvenční analýza DNA MeSH
- Staphylococcus fyziologie genetika izolace a purifikace klasifikace MeSH
- techniky typizace bakterií MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Geografické názvy
- Jižní Amerika MeSH
