51 l. : il. ; 21 cm
The HMG-box domain of approximately 75 amino acid residues was originally identified as the domain that mediates the DNA-binding of chromatin-associated high-mobility group (HMG) proteins of the HMGB type. In the last few years, HMG-box domains have been found in various DNA-binding proteins including transcription factors and subunits of chromatin-remodeling complexes. HMG-box domains mediate either non-sequence-specific (e.g., HMGB-type proteins) or sequence-specific (e.g., transcription factors) DNA binding. Both types of HMG-box domains bind non-B-type DNA structures (bent, kinked and unwound) with high affinity. In addition, HMG-box domains are involved in a variety of protein-protein interactions. Here, we have examined the human and plant genomes for genes encoding HMG-box domains. Compared to plants, human cells contain a larger variety of HMG-box proteins. Whereas in humans transcription factors are the most divergent group of HMG-box proteins, in plants the chromosomal HMGB-type proteins are most variable.
- MeSH
- DNA vazebné proteiny MeSH
- domény HMG-Box MeSH
- financování organizované MeSH
- genom lidský MeSH
- genom rostlinný MeSH
- jaderné proteiny MeSH
- lidé MeSH
- proteiny Drosophily MeSH
- proteiny HMGB MeSH
- restrukturace chromatinu MeSH
- transkripční faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
