Zvýšený oxidační stres při cévních onemocněních stimuluje sekreci adipokinů z adipocytů. Řada klinických studií prokázala, že hodnoty adipsinu v plazmě poměrně spolehlivě predikují vznik ischemických příhod. Zvýšené hodnoty adipsinu těsně souvisejí s úmrtím z jakýchkoli příčin a s morbiditou. Adipsin je tak novým biomarkerem při sledování rozvoje aterosklerózy. Cílem tohoto přehledu bylo zdůraznit souvislost mezi adipsinem a kardiovaskulárními onemocněními a přínos použití adipsinu v léčbě těchto onemocnění.

Increased vascular oxidative stress stimulates the secretion of adipokines from adipocytes. Many clinical studies have demonstrated that plasma adipsin levels are successful in predicting ischemic events. Increased adipsin levels are closely related to all-cause death and morbidity. Therefore, adipsin may be a new biomarker for atherosclerosis. In this review, we aimed to emphasize the association of adipsin with cardiovascular diseases (CVDs) and its beneficial role in the therapeutic field of CVDs.

• Keywords
• Adipsin, Atherosclerosis, Cardiovascular disease, Adipsin, Ateroskleróza, Kardiovaskulární onemocnění,
• MeSH
• Atherosclerosis diagnosis   physiopathology   MeSH
• Biomarkers analysis   MeSH
• Cardiovascular Diseases * diagnosis   physiopathology   MeSH
• Complement Factor D * analysis   physiology   adverse effects   MeSH
• Humans MeSH
• Oxidative Stress MeSH
• Prognosis MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

Peripheral insulin resistance is associated with decreasing adiponectin and increasing leptin plasma levels, and also with cognitive decline. The effects of adipokines on brain function have been published from both animal and human studies. In particular, the influence of leptin and adiponectin on the development of Alzheimer's disease (AD) has been extensively investigated. However, the association between adipsin and AD is as yet unknown. In 37 patients with AD and 65 controls that followed the same study protocol, we tested whether adiponectin, leptin, and adipsin could be used as biomarkers in the early stages of AD. In contrast with conclusions of cognition studies in insulin resistant states, our study found a correlation of impaired neuropsychological performance with increasing adiponectin and decreasing leptin in AD patients. Nevertheless, no significant differences between patients and controls were found. AD women had significantly increased adipsin compared to controls, and there was a positive correlation of adipsin with age and disease duration. Although adipokines do not appear to be suitable biomarkers for early AD diagnosis, they certainly play a role in the pathogenesis of AD. Further studies will be needed to explain the cause of the adipokine "breaking point" that leads to the pathogenesis of overt AD.

• MeSH
• Adiponectin blood   MeSH
• Alzheimer Disease blood   pathology   MeSH
• Biomarkers blood   MeSH
• Complement Factor D analysis   MeSH
• Leptin blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Case-Control Studies MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

AIMS: This study was designed to investigate the relationship between 8 selected adipokines (leptin, leptin receptor, adiponectin, agouti-related peptide, omentin, visfatin, adipsin and resistin), dietary composition and anthropometric parameters found in the Central European obese population. METHODS: A total of 65 unrelated obese Central European Caucasian individuals were recruited for the study. Phenotypic measurements included weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness. Participants completed standardized self-reported 7-day food records. Plasma levels of leptin, leptin receptor, adiponectin, agouti-related peptide (AgRP), resistin, adipsin, omentin and visfatin were examined using ELISA. RESULTS: Multiple associations (weight, height, percentage of body fat, waist circumference, hip circumference, WHR and sum of skinfold thickness) with the circulation levels of the investigated adipokines were identified. Leptin-Leptin receptor (L-LR) levels were found to correlate with total energy intake and macronutrients while adipsin was found to strongly correlate with multiple adipokines. Furthermore, the L-LR index was found to constitute a more accurate description of the relationship between BMI and body weight than individual measurements and the Ag-LR index was found to strongly correlate with both anthropometric and dietary characteristics. CONCLUSION: Following confirmation on larger population samples and on samples of different ethnicities, the reported adipokine indexes could become a useful tool for estimating nutritional status and predicting the body composition of specific patient groups.

• MeSH
• Adipokines blood   MeSH
• Adiponectin blood   MeSH
• Agouti-Related Protein blood   MeSH
• Anthropometry * MeSH
• Biomarkers blood   MeSH
• Cytokines blood   MeSH
• Diet statistics & numerical data   MeSH
• Adult MeSH
• GPI-Linked Proteins blood   MeSH
• Complement Factor D analysis   MeSH
• Lectins blood   MeSH
• Leptin blood   MeSH
• Receptors, Leptin blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Nicotinamide Phosphoribosyltransferase blood   MeSH
• Nutritional Status * MeSH
• Obesity blood   MeSH
• Resistin blood   MeSH
• Health Status Indicators * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH